東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Protective mechanisms against oxidat...

Yaung, Jennifer.

Linked to FindBook

Google Book

Amazon

博客來

Protective mechanisms against oxidative stress in retinal pathogenesis.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Protective mechanisms against oxidative stress in retinal pathogenesis./
Author:	Yaung, Jennifer.
Description:	186 p.
Notes:	Adviser: David R. Hinton.
Contained By:	Dissertation Abstracts International68-05B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3262711
ISBN:	9780549002314

Protective mechanisms against oxidative stress in retinal pathogenesis.
Yaung, Jennifer.

Protective mechanisms against oxidative stress in retinal pathogenesis. - 186 p.

Adviser: David R. Hinton.

Thesis (Ph.D.)--University of Southern California, 2007.

Ample evidence suggests that oxidative stress and other external stressors contribute to retinal and retinal pigment epithelium (RPE) pathology, as implicated in diseases like age-related macular degeneration. Therefore the understanding of cellular protection against these insults is of therapeutic importance. We adapted two approaches for studying the mechanisms of macular and retinal degeneration. In one, the contribution and significance of these pathologic processes was investigated by use of cultured human and mouse RPE. In the in vivo counterpart studies, we assessed the importance of alpha-crystallins in the retina (and RPE) in models using knockout mice and cobalt chloride injections. In addition to alpha-crystallins, we looked at other oxidative stress protectants of the cell and examined the redox regulation and antioxidant functions mediated by hepatocyte growth factor (HGF). These studies have greatly contributed to the elucidation of the pathways involved in retinal dysfunction and examine the protective mechanisms offered by hepatocyte growth factor and alpha-crystallins in oxidative-stressed retina.

ISBN: 9780549002314Subjects--Topical Terms:

1017686
Biology, Cell.

Protective mechanisms against oxidative stress in retinal pathogenesis.
LDR:02040nam 2200289 a 45 001 967738
005 20110915
008 110915s2007 eng d
020 $a 9780549002314
035 $a (UMI)AAI3262711
035 $a AAI3262711
040 $a UMI $c UMI
100 1 $a Yaung, Jennifer. $3 1291607
245 1 0 $a Protective mechanisms against oxidative stress in retinal pathogenesis.
300 $a 186 p.
500 $a Adviser: David R. Hinton.
500 $a Source: Dissertation Abstracts International, Volume: 68-05, Section: B, page: 2765.
502 $a Thesis (Ph.D.)--University of Southern California, 2007.
520 $a Ample evidence suggests that oxidative stress and other external stressors contribute to retinal and retinal pigment epithelium (RPE) pathology, as implicated in diseases like age-related macular degeneration. Therefore the understanding of cellular protection against these insults is of therapeutic importance. We adapted two approaches for studying the mechanisms of macular and retinal degeneration. In one, the contribution and significance of these pathologic processes was investigated by use of cultured human and mouse RPE. In the in vivo counterpart studies, we assessed the importance of alpha-crystallins in the retina (and RPE) in models using knockout mice and cobalt chloride injections. In addition to alpha-crystallins, we looked at other oxidative stress protectants of the cell and examined the redox regulation and antioxidant functions mediated by hepatocyte growth factor (HGF). These studies have greatly contributed to the elucidation of the pathways involved in retinal dysfunction and examine the protective mechanisms offered by hepatocyte growth factor and alpha-crystallins in oxidative-stressed retina.
590 $a School code: 0208.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Ophthalmology. $3 1019445
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0379
690 $a 0381
690 $a 0571
710 2 0 $a University of Southern California. $b Pathobiology. $3 1291608
773 0 $t Dissertation Abstracts International $g 68-05B.
790 $a 0208
790 1 0 $a Hinton, David R., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3262711