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Precise and accurate structural geno...

Shen, Yang.

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Precise and accurate structural genomics protein structure determination using RD and GFT NMR spectroscopy.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Precise and accurate structural genomics protein structure determination using RD and GFT NMR spectroscopy./
作者:	Shen, Yang.
面頁冊數:	161 p.
附註:	Advisers: Jim D. Atwood; Thomas Szyperski.
Contained By:	Dissertation Abstracts International66-12B.
標題:	Chemistry, Physical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3203956
ISBN:	9780542498466

Precise and accurate structural genomics protein structure determination using RD and GFT NMR spectroscopy.
Shen, Yang.

Precise and accurate structural genomics protein structure determination using RD and GFT NMR spectroscopy. - 161 p.

Advisers: Jim D. Atwood; Thomas Szyperski.

Thesis (Ph.D.)--State University of New York at Buffalo, 2006.

Nuclear magnetic resonance (NMR) has emerged as a powerful tool for determining three-dimensional structures of proteins in solution. The major part of this dissertation describes the efforts to deal with the core steps involved in NMR-base protein structure determination: NMR data collection, NMR data analysis, structure calculation and refinement.

ISBN: 9780542498466Subjects--Topical Terms:

560527
Chemistry, Physical.

Precise and accurate structural genomics protein structure determination using RD and GFT NMR spectroscopy.
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245 1 0 $a Precise and accurate structural genomics protein structure determination using RD and GFT NMR spectroscopy.
300 $a 161 p.
500 $a Advisers: Jim D. Atwood; Thomas Szyperski.
500 $a Source: Dissertation Abstracts International, Volume: 66-12, Section: B, page: 6650.
502 $a Thesis (Ph.D.)--State University of New York at Buffalo, 2006.
520 $a Nuclear magnetic resonance (NMR) has emerged as a powerful tool for determining three-dimensional structures of proteins in solution. The major part of this dissertation describes the efforts to deal with the core steps involved in NMR-base protein structure determination: NMR data collection, NMR data analysis, structure calculation and refinement.
520 $a NMR data collection has been recognized as one of the major bottlenecks of NMR-base structure determination due to the necessarily long time. Chapter 2 and 3 describe two NMR data collection and analysis protocols for high-quality protein structure determination based on Reduced Dimensionality (RD) and G-matrix Fourier transform (GFT) NMR, respectively. The rapidly collected RD & GFT NMR data enabled high-quality structure determination of four structural genomics target proteins in high-throughput. Chapter 5 introduces the program UBNMR which was developed to facilitate NMR data analysis in general and RD & GFT NMR data pre-processing and data analysis in particular. RD and GFT NMR based protocols, with the aid of UBNMR, are expected to greatly impact on the NMR-based structural biology and structural genomics.
520 $a In addition to rapid NMR data collection and analysis, structure calculation and refinement are also pivotal for obtaining the high-quality protein structures. Chapter 5 describes the analysis of the newly implemented simultaneous GFT NOESY to obtain an accurate and precise initial structural fold. Chapter 6 presents a protein structure refinement strategy using NOE data collected in supercooled water at low temperatures.
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