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Working memory in electrically injur...

Ramati, Alona.

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Working memory in electrically injured patients: A functional neuroimaging study.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Working memory in electrically injured patients: A functional neuroimaging study./
Author:	Ramati, Alona.
Description:	120 p.
Notes:	Adviser: Roland Erwin.
Contained By:	Dissertation Abstracts International67-04B.
Subject:	Psychology, Clinical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3215146
ISBN:	9780542648311

Working memory in electrically injured patients: A functional neuroimaging study.
Ramati, Alona.

Working memory in electrically injured patients: A functional neuroimaging study. - 120 p.

Adviser: Roland Erwin.

Thesis (Ph.D.)--Rosalind Franklin University of Medicine and Science, 2006.

Studies examining cognitive functioning in electrical injury patients using behavioral measures consistently report neuropsychological deficits primarily in attention, learning and working memory domains. To date, it remains unclear whether the observed cognitive dysfunction has an organic basis. The current study sought to examine whether electrical injury subjects demonstrate abnormal patterns of brain activation during working memory and implicit learning tasks. Fourteen electrical injury subjects and fifteen demographically matched healthy control subjects performed two oculomotor cognitive activation tasks during functional magnetic resonance imaging studies. Behavioral performance data was also collected in an oculomotor neurophysiological laboratory using the same oculomotor paradigms. For the spatial working memory task, electrical injury subjects exhibited significantly more activation in and around all sensory-motor areas supporting working memory including the prefrontal cortex, posterior somatosensory cortices, cingulated cortex and striatum. An inverse pattern of between-group differences in activation was observed on the implicit learning task, with electrical injury subjects exhibiting significantly reduced activation in all brain regions activated by controls. Behavioral data indicates mostly comparable level of task performance in terms of accuracy, though significantly longer response latencies in the electrical injury group on the implicit learning and visually-guided saccade tasks. These results suggest task-dependent, system-level dysfunction of cortical and subcortical regions that support working memory and implicit learning. This is the first study to demonstrate neuronal functional abnormalities following electrical injury.

ISBN: 9780542648311Subjects--Topical Terms:

524864
Psychology, Clinical.

Working memory in electrically injured patients: A functional neuroimaging study.
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035 $a (UMI)AAI3215146
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100 1 $a Ramati, Alona. $3 1291151
245 1 0 $a Working memory in electrically injured patients: A functional neuroimaging study.
300 $a 120 p.
500 $a Adviser: Roland Erwin.
500 $a Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 2239.
502 $a Thesis (Ph.D.)--Rosalind Franklin University of Medicine and Science, 2006.
520 $a Studies examining cognitive functioning in electrical injury patients using behavioral measures consistently report neuropsychological deficits primarily in attention, learning and working memory domains. To date, it remains unclear whether the observed cognitive dysfunction has an organic basis. The current study sought to examine whether electrical injury subjects demonstrate abnormal patterns of brain activation during working memory and implicit learning tasks. Fourteen electrical injury subjects and fifteen demographically matched healthy control subjects performed two oculomotor cognitive activation tasks during functional magnetic resonance imaging studies. Behavioral performance data was also collected in an oculomotor neurophysiological laboratory using the same oculomotor paradigms. For the spatial working memory task, electrical injury subjects exhibited significantly more activation in and around all sensory-motor areas supporting working memory including the prefrontal cortex, posterior somatosensory cortices, cingulated cortex and striatum. An inverse pattern of between-group differences in activation was observed on the implicit learning task, with electrical injury subjects exhibiting significantly reduced activation in all brain regions activated by controls. Behavioral data indicates mostly comparable level of task performance in terms of accuracy, though significantly longer response latencies in the electrical injury group on the implicit learning and visually-guided saccade tasks. These results suggest task-dependent, system-level dysfunction of cortical and subcortical regions that support working memory and implicit learning. This is the first study to demonstrate neuronal functional abnormalities following electrical injury.
590 $a School code: 1489.
650 4 $a Psychology, Clinical. $3 524864
650 4 $a Psychology, Cognitive. $3 1017810
650 4 $a Psychology, Psychobiology. $3 1017821
690 $a 0349
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690 $a 0633
710 2 0 $a Rosalind Franklin University of Medicine and Science. $3 1025147
773 0 $t Dissertation Abstracts International $g 67-04B.
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790 1 0 $a Erwin, Roland, $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3215146