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Molecular hydrogels: Design, synthes...
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Yang, Zhimou.
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Molecular hydrogels: Design, synthesis, enzymatic regulation, and biological applications.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Molecular hydrogels: Design, synthesis, enzymatic regulation, and biological applications./
作者:
Yang, Zhimou.
面頁冊數:
207 p.
附註:
Adviser: Bing Xu.
Contained By:
Dissertation Abstracts International67-12B.
標題:
Chemistry, Polymer. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3245375
Molecular hydrogels: Design, synthesis, enzymatic regulation, and biological applications.
Yang, Zhimou.
Molecular hydrogels: Design, synthesis, enzymatic regulation, and biological applications.
- 207 p.
Adviser: Bing Xu.
Thesis (Ph.D.)--Hong Kong University of Science and Technology (People's Republic of China), 2006.
We have used the techniques of SEM, TEM, Rheology, Fluorescent spectra, CD spectra to characterize all the molecular hydrogels and also described the data of pHgel-Sol, Tgel-sol and Cmin in this thesis.Subjects--Topical Terms:
1018428
Chemistry, Polymer.
Molecular hydrogels: Design, synthesis, enzymatic regulation, and biological applications.
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Source: Dissertation Abstracts International, Volume: 67-12, Section: B, page: 7114.
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In this thesis, we designed and synthesized some novel molecular hydrogelators based on short peptides or amino acids. They showed responses to environmental changes such as pH, temperature, ionic strength or catalytic reactions by enzymes. We divided the thesis into three parts. In part I, we reported the molecular hydrogels response to ligand-receptor interactions. The D-Ala-D-Ala-based hydrogels show responses to the addition of vacomycin. In part II, we talked about enzymatic regulations of molecular hydrogels. We used different enzymes (phosphatase, esterase, MMP-9, beta-lactamase) or enzymatic switch (phosphase/kinase) to control the self-assembly of small molecules in vitro or in vivo. In part III, we introduced the syntheses of novel molecular hydrogelators based on amino acids, short peptides as well as antibiotic. They formed single or multi-component hydrogels. We also reported the applications of the molecular hydrogels, including the detection of inhibitors of enzyme, removal uranium ions from the wounds on mouse, killing bacteria, etc.
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