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Synthesis and solution properties of...

Passeno, Leslie Michele.

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Synthesis and solution properties of dendrimers and linear-dendrimer diblock copolymers.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Synthesis and solution properties of dendrimers and linear-dendrimer diblock copolymers./
Author:	Passeno, Leslie Michele.
Description:	274 p.
Notes:	Adviser: Gregory L. Baker.
Contained By:	Dissertation Abstracts International67-10B.
Subject:	Chemistry, Organic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3236395
ISBN:	9780542909429

Synthesis and solution properties of dendrimers and linear-dendrimer diblock copolymers.
Passeno, Leslie Michele.

Synthesis and solution properties of dendrimers and linear-dendrimer diblock copolymers. - 274 p.

Adviser: Gregory L. Baker.

Thesis (Ph.D.)--Michigan State University, 2006.

Dendrimer-linear diblock copolymers have potential applications as molecular sensor and drug delivery vehicles, among other uses, by manipulation of the dendrimer block's size and conformation. We synthesized and investigated the conformation of these diblocks in solution, with particular emphasis on probing the location of the linear chain with respect to the dendrimer in a variety of environmental conditions.

ISBN: 9780542909429Subjects--Topical Terms:

516206
Chemistry, Organic.

Synthesis and solution properties of dendrimers and linear-dendrimer diblock copolymers.
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020 $a 9780542909429
035 $a (UMI)AAI3236395
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040 $a UMI $c UMI
100 1 $a Passeno, Leslie Michele. $3 1287329
245 1 0 $a Synthesis and solution properties of dendrimers and linear-dendrimer diblock copolymers.
300 $a 274 p.
500 $a Adviser: Gregory L. Baker.
500 $a Source: Dissertation Abstracts International, Volume: 67-10, Section: B, page: 5785.
502 $a Thesis (Ph.D.)--Michigan State University, 2006.
520 $a Dendrimer-linear diblock copolymers have potential applications as molecular sensor and drug delivery vehicles, among other uses, by manipulation of the dendrimer block's size and conformation. We synthesized and investigated the conformation of these diblocks in solution, with particular emphasis on probing the location of the linear chain with respect to the dendrimer in a variety of environmental conditions.
520 $a Neutron scattering from a poly(styrene)-poly(benzyl ether) (PS PBE) linear-dendrimer diblock revealed the system underwent a single molecule phase transition. The dendrimer expelled the linear polymer from its cavities to the surrounding solvent and changed shape as the molecular weight of the linear polymer increased. This unusual behavior demonstrates the potential for this class of architecturally asymmetric molecules to perform as molecular machines. Since we believe it is the relative size of the linear polymer to the dendron that is responsible for this transition a second system was studied to test this hypothesis.
520 $a We investigated a poly(ethylene oxide)-poly(amido amine) (PEO-PAMAM) linear-dendrimer diblock since the PAMAM dendrimer can undergo a significant size change that depends on solvent environment and molecular weight (generation number). The PAMAM dendron was synthesized from a 2-methoxyethylamine core by exhaustive Michael addition with methyl acrylate followed by amidation with ethylene-diamine to create the first generation. These steps were repeated until the desired generation was obtained. Small angle neutron scattering experiments of PAMAM solutions revealed that the fourth generation dendrimer had the greatest volume change as expected from a simple scaling theory. In addition, fluorescence measurements of dansyl-cored PAMAM di-dendrons reveal a change in morphology at generation 4 from an extended to a globular morphology. This generation is anticipated to have the most utility as a molecular machine and was the target for the synthesis of PEO-PAMAM linear dendrimer diblocks. Dynamic light scattering of the PEO-PAMAM hybrids in water demonstrates that the hydrodynamic radius (Rh) goes through a transition as the molecular weight of the PEO chain increases. At low hybrid molecular weights the Rh is smaller than a PEO chain with analogous molecular weight. When the molecular weight of the linear PEO chain is increased the Rh of the hybrid is equal to that of an analogous PEO chain. This transition parallels that of the PS-PBE system, demonstrating that the relative molecular weight of the linear and dendrimer blocks, along with the dendrimers' ability to change morphology in response to its surrounding environment, allows the hybrid systems to change conformation.
590 $a School code: 0128.
650 4 $a Chemistry, Organic. $3 516206
650 4 $a Chemistry, Polymer. $3 1018428
690 $a 0490
690 $a 0495
710 2 0 $a Michigan State University. $3 676168
773 0 $t Dissertation Abstracts International $g 67-10B.
790 $a 0128
790 1 0 $a Baker, Gregory L., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3236395