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Novel animal models to study the rol...

Wang, Zhuohua.

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Novel animal models to study the role of the GH/IGF axis in prostate cancer.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Novel animal models to study the role of the GH/IGF axis in prostate cancer./
Author:	Wang, Zhuohua.
Description:	176 p.
Notes:	Adviser: Steven M. Swanson.
Contained By:	Dissertation Abstracts International68-01B.
Subject:	Health Sciences, Oncology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3248451

Novel animal models to study the role of the GH/IGF axis in prostate cancer.
Wang, Zhuohua.

Novel animal models to study the role of the GH/IGF axis in prostate cancer. - 176 p.

Adviser: Steven M. Swanson.

Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2006.

Overall, results from the animal models developed in this dissertation suggest that components of the GH/IGF axis may represent important targets for the development of novel agents to prevent and treat prostate cancer.Subjects--Topical Terms:

1018566
Health Sciences, Oncology.

Novel animal models to study the role of the GH/IGF axis in prostate cancer.
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005 20110901
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035 $a (UMI)AAI3248451
035 $a AAI3248451
040 $a UMI $c UMI
100 1 $a Wang, Zhuohua. $3 1287198
245 1 0 $a Novel animal models to study the role of the GH/IGF axis in prostate cancer.
300 $a 176 p.
500 $a Adviser: Steven M. Swanson.
500 $a Source: Dissertation Abstracts International, Volume: 68-01, Section: B, page: 0223.
502 $a Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2006.
520 $a Overall, results from the animal models developed in this dissertation suggest that components of the GH/IGF axis may represent important targets for the development of novel agents to prevent and treat prostate cancer.
520 $a Prostate cancer is the most common non-skin cancer in man. The purpose of this dissertation study was to establish the first animal models to directly test the hypothesis that a normal, functional GH/IGF-I axis is required for prostate cancer progression.
520 $a The Tag/Ghr-/- mouse was established by crossing the GHR/BP knockout mouse with the C3(1)/Tag mouse. This new mouse strain demonstrated that prostate cancer progression from Tag-initiated epithelial cells to prostate intraepithelial neoplasia (PIN) was significantly inhibited in the absence of GHR. Disruption of the GHR gene did not alter the expression of the Tag oncogene, prostate androgen receptor (AR) or serum testosterone titers. Cancer inhibition appears to be associated with decreased proliferation and increased apoptosis of the prostate epithelium of Tag/Ghr -/- mice. These findings suggest that PIN may require GH signaling for progression.
520 $a The Tag/Ghdr/dr rat model was established by crossing the spontaneous dwarf rat with the Probasin/Tag rat. Evaluation of carcinogenesis in this model indicated that prostate cancer progression induced by Tag was significantly inhibited in the absence of GH signaling. Prostate tumor incidence was significantly reduced, tumor latency was delayed and tumor burden was significantly reduced in Tag/Ghdr/dr rats relative to Tag/Gh+/+ controls. At 25 weeks of age, loss of GH resulted in a 20% and 80% decrease (P < 0.05 and P < 0.0001) in the area of microinvasive carcinoma in the dorsal and lateral lobes, respectively. By 52 weeks of age, invasive prostate adenocarcinomas were observed in all Tag/Gh+/+ rats with metastasis, while the majority of Tag/Ghdr/dr did not develop invasive tumors. The absence of GH did not affect expression of the Tag oncogene, prostate AR or serum testosterone titers. Cancer inhibition appeared to be associated with decreased prostate GHR expression and increased prostate IGF-1R expression in Tag/Ghdr/dr rats. These findings suggest that an intact GH signaling plays an important role in progression from latent to malignant prostate cancer.
590 $a School code: 0806.
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0419
690 $a 0992
710 2 0 $a University of Illinois at Chicago, Health Sciences Center. $3 1021703
773 0 $t Dissertation Abstracts International $g 68-01B.
790 $a 0806
790 1 0 $a Swanson, Steven M., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3248451