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Microanalyses of amphetamine-induced...

Thisayakorn, Krittiya.

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Microanalyses of amphetamine-induced behaviors: Dose-effect studies in four different rat strains.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Microanalyses of amphetamine-induced behaviors: Dose-effect studies in four different rat strains./
Author:	Thisayakorn, Krittiya.
Description:	210 p.
Notes:	Adviser: Stephen C. Fowler.
Contained By:	Dissertation Abstracts International67-09B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3235011
ISBN:	9780542884047

Microanalyses of amphetamine-induced behaviors: Dose-effect studies in four different rat strains.
Thisayakorn, Krittiya.

Microanalyses of amphetamine-induced behaviors: Dose-effect studies in four different rat strains. - 210 p.

Adviser: Stephen C. Fowler.

Thesis (Ph.D.)--University of Kansas, 2006.

Repeated administration of amphetamine causes a progressive increase in behavioral response referred to as behavioral sensitization. Amphetamine sensitized rats show two types of behavioral sensitization depending on the dose administered. However, the degree of behavioral sensitization may vary with rat strain and may have a genetic component. Based on recordings of a 4-hr session provided by a force-plate actometer, three variables reflecting sensitization: distance traveled, focused stereotypy scores, and spatial confinement, were measured. The behavioral differences and sensitivities in response to doses of amphetamine were studied among four rat strains. Fischer 344 (F344) and Spontaneous Hypertensive Rat (SHR) expressed high scores of focused stereotypy with 2.5 mg/kg amphetamine along with high levels of spatial confinement and decreased distance traveled, whereas Sprague Dawley (SD) and Wistar-Kyoto (WKY) rats showed high responses to 5.0 mg/kg dose. Inspection of the power spectra of the vertical force component from the actometer showed that SD rats exhibited high intensity rhythmic head movements with a frequency range of 8-10 Hz in response to 5.0 mg/kg. In contrast, F344 and SHR rats exhibited lower, broader frequencies and lower intensities of the head movements than the SD did. Serum concentrations of amphetamine were measured to determine if the behavioral differences were related to differences in blood level of amphetamine in these rat strains. Serum levels were closely similar in the four strains after 5.0 mg/kg and 2.5 mg/kg doses. Vibrissotomy was studied in SD and F344 rats to test the hypothesis that the vibrissae were involved in the generation of the 10 Hz rhythm. The lack of vibrissae significantly affected amphetamine responses of SD and F344 rats at low and high, but not medium doses of amphetamine. However, vibrissotomy did not diminish the repetition nor substantially change the head movement rhythms during focused stereotypy. The differences in behavioral sensitivity to amphetamine among the four strains in the context of the similar serum levels suggests pharmacodynamic strain differences that probably will be traceable to genetic differences. The data imply that rat strain is an important variable in laboratory studies attempting to model psychiatric or drug addition disorders in humans.

ISBN: 9780542884047Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Microanalyses of amphetamine-induced behaviors: Dose-effect studies in four different rat strains.
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100 1 $a Thisayakorn, Krittiya. $3 1287136
245 1 0 $a Microanalyses of amphetamine-induced behaviors: Dose-effect studies in four different rat strains.
300 $a 210 p.
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500 $a Source: Dissertation Abstracts International, Volume: 67-09, Section: B, page: 5010.
502 $a Thesis (Ph.D.)--University of Kansas, 2006.
520 $a Repeated administration of amphetamine causes a progressive increase in behavioral response referred to as behavioral sensitization. Amphetamine sensitized rats show two types of behavioral sensitization depending on the dose administered. However, the degree of behavioral sensitization may vary with rat strain and may have a genetic component. Based on recordings of a 4-hr session provided by a force-plate actometer, three variables reflecting sensitization: distance traveled, focused stereotypy scores, and spatial confinement, were measured. The behavioral differences and sensitivities in response to doses of amphetamine were studied among four rat strains. Fischer 344 (F344) and Spontaneous Hypertensive Rat (SHR) expressed high scores of focused stereotypy with 2.5 mg/kg amphetamine along with high levels of spatial confinement and decreased distance traveled, whereas Sprague Dawley (SD) and Wistar-Kyoto (WKY) rats showed high responses to 5.0 mg/kg dose. Inspection of the power spectra of the vertical force component from the actometer showed that SD rats exhibited high intensity rhythmic head movements with a frequency range of 8-10 Hz in response to 5.0 mg/kg. In contrast, F344 and SHR rats exhibited lower, broader frequencies and lower intensities of the head movements than the SD did. Serum concentrations of amphetamine were measured to determine if the behavioral differences were related to differences in blood level of amphetamine in these rat strains. Serum levels were closely similar in the four strains after 5.0 mg/kg and 2.5 mg/kg doses. Vibrissotomy was studied in SD and F344 rats to test the hypothesis that the vibrissae were involved in the generation of the 10 Hz rhythm. The lack of vibrissae significantly affected amphetamine responses of SD and F344 rats at low and high, but not medium doses of amphetamine. However, vibrissotomy did not diminish the repetition nor substantially change the head movement rhythms during focused stereotypy. The differences in behavioral sensitivity to amphetamine among the four strains in the context of the similar serum levels suggests pharmacodynamic strain differences that probably will be traceable to genetic differences. The data imply that rat strain is an important variable in laboratory studies attempting to model psychiatric or drug addition disorders in humans.
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