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Coordinating the heartbeat: Developm...

Rentschler, Stacey Lynn.

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Coordinating the heartbeat: Development of the cardiac conduction system.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Coordinating the heartbeat: Development of the cardiac conduction system./
作者:	Rentschler, Stacey Lynn.
面頁冊數:	106 p.
附註:	Adviser: Glenn I. Fishman.
Contained By:	Dissertation Abstracts International63-05B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3054076
ISBN:	9780493680248

Coordinating the heartbeat: Development of the cardiac conduction system.
Rentschler, Stacey Lynn.

Coordinating the heartbeat: Development of the cardiac conduction system. - 106 p.

Adviser: Glenn I. Fishman.

Thesis (Ph.D.)--Mount Sinai School of Medicine of New York University, 2002.

The cardiac conduction system is a complex network of cells that orchestrates the rhythmic and coordinated depolarization of the heart. The mechanisms regulating specification and patterning of the conductive network are largely unknown. Studies in avian models have suggested that components of the cardiac conduction system arise from progressive recruitment of cardiomyogenic progenitors throughout in ovo development. However, relatively little is known about the process of conduction system development in mammals, especially in the mouse, where even the identification of components of the conductive network remains problematic.

ISBN: 9780493680248Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Coordinating the heartbeat: Development of the cardiac conduction system.
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245 1 0 $a Coordinating the heartbeat: Development of the cardiac conduction system.
300 $a 106 p.
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502 $a Thesis (Ph.D.)--Mount Sinai School of Medicine of New York University, 2002.
520 $a The cardiac conduction system is a complex network of cells that orchestrates the rhythmic and coordinated depolarization of the heart. The mechanisms regulating specification and patterning of the conductive network are largely unknown. Studies in avian models have suggested that components of the cardiac conduction system arise from progressive recruitment of cardiomyogenic progenitors throughout in ovo development. However, relatively little is known about the process of conduction system development in mammals, especially in the mouse, where even the identification of components of the conductive network remains problematic.
520 $a In this thesis we describe the CCS-lacZ line of transgenic mice, where lacZ reporter gene expression delineates the full extent of the developing and mature murine cardiac conduction system, extending from the sinoatrial node to the distal Purkinje fibers. Optical mapping of cardiac electrical activity confirms that cells expressing the lacZ reporter gene are indeed components of the specialized conduction system. Analysis of lacZ expression during sequential stages of cardiogenesis provides a detailed view of the maturation of the conductive network and its interconnections in the mammalian heart. Characterization of ventricular activation patterns at several stages of heart development determines the stages during which components of the embryonic conduction system become functional. In comparison with the prevailing model of avian conduction system development, these studies demonstrate that the mammalian conduction system is patterned and functioning earlier than its avian counterpart.
520 $a Since the conduction system develops in close association with the endocardium, we tested the ability of several endocardial-derived paracrine factors to convert contractile cardiomyocytes into conduction system cells as assesed by ectopic reporter gene expression in CCS-lacZ hearts. We show that neuregulin-1, a growth and differentiation factor essential for ventricular trabeculation, is sufficient to ectopically induce expression of this conduction system marker in the heart. This inductive effect of neuregulin-1 is restricted to a window of sensitivity between 8.5--10.5 d.p.c. Therefore, we propose that endocardial-derived neuregulins may be the major endogenous ligands responsible for transdifferentiation of murine embryonic cardiomyocytes into cells of the conduction system.
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