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Methods to produce silk fibroin film...

Lawrence, Brian D.

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Methods to produce silk fibroin film biomaterials for applications in corneal tissue regeneration.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Methods to produce silk fibroin film biomaterials for applications in corneal tissue regeneration./
Author:	Lawrence, Brian D.
Description:	134 p.
Notes:	Adviser: David L. Kaplan.
Contained By:	Masters Abstracts International46-05.
Subject:	Biophysics, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1450793
ISBN:	9780549522386

Methods to produce silk fibroin film biomaterials for applications in corneal tissue regeneration.
Lawrence, Brian D.

Methods to produce silk fibroin film biomaterials for applications in corneal tissue regeneration. - 134 p.

Adviser: David L. Kaplan.

Thesis (M.S.)--Tufts University, 2008.

Silk fibroin derived from the Bombyx mori silk worm cocoon offers a unique choice in biomaterial selection for uses in tissue engineering and regenerative medicine. This is primarily due to fibroin's non-immunogenic response upon in vivo implantation; controllable material degradation rates; tunable mechanical properties; and ambient processing conditions. Silk fibroin films can be generated to produce simplified geometries with highly controlled material properties that offer substrates capable of successfully interfacing with biological systems. In addition, a variety of silk film processing methods exist to tailor these biomaterial properties to a given application. Current biomaterials for use in corneal tissue regeneration do not possess the range of material properties and processing combinations as offered by silk fibroin. Therefore, studies were carried out to assess silk fibroin film processing methods and in vitro corneal cell response to better characterize these biomaterials for use in cornea related applications. Processing methods were developed to generate silk film biomaterials with high resolution surface patterns, controllable film thickness and porosity, and ensured sterility. Silk films generated from these methods were found to support corneal fibroblast growth, guide cell and ECM alignment, and could be assembled to form 3D corneal tissue constructs. The results from these studies demonstrate that silk films offer a new option in biomaterial choice for the development of clinically relevant corneal devices to aid in tissue regeneration.

ISBN: 9780549522386Subjects--Topical Terms:

1019105
Biophysics, General.

Methods to produce silk fibroin film biomaterials for applications in corneal tissue regeneration.
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100 1 $a Lawrence, Brian D. $3 1281086
245 1 0 $a Methods to produce silk fibroin film biomaterials for applications in corneal tissue regeneration.
300 $a 134 p.
500 $a Adviser: David L. Kaplan.
500 $a Source: Masters Abstracts International, Volume: 46-05, page: 2746.
502 $a Thesis (M.S.)--Tufts University, 2008.
520 $a Silk fibroin derived from the Bombyx mori silk worm cocoon offers a unique choice in biomaterial selection for uses in tissue engineering and regenerative medicine. This is primarily due to fibroin's non-immunogenic response upon in vivo implantation; controllable material degradation rates; tunable mechanical properties; and ambient processing conditions. Silk fibroin films can be generated to produce simplified geometries with highly controlled material properties that offer substrates capable of successfully interfacing with biological systems. In addition, a variety of silk film processing methods exist to tailor these biomaterial properties to a given application. Current biomaterials for use in corneal tissue regeneration do not possess the range of material properties and processing combinations as offered by silk fibroin. Therefore, studies were carried out to assess silk fibroin film processing methods and in vitro corneal cell response to better characterize these biomaterials for use in cornea related applications. Processing methods were developed to generate silk film biomaterials with high resolution surface patterns, controllable film thickness and porosity, and ensured sterility. Silk films generated from these methods were found to support corneal fibroblast growth, guide cell and ECM alignment, and could be assembled to form 3D corneal tissue constructs. The results from these studies demonstrate that silk films offer a new option in biomaterial choice for the development of clinically relevant corneal devices to aid in tissue regeneration.
590 $a School code: 0234.
650 4 $a Biophysics, General. $3 1019105
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Materials Science. $3 1017759
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710 2 $a Tufts University. $b Biomedical Engineering. $3 1023780
773 0 $t Masters Abstracts International $g 46-05.
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790 1 0 $a Kaplan, David L., $e advisor
790 1 0 $a Marchant, Jeffrey K. $e committee member
790 1 0 $a Omenetto, Fiorenzo G. $e committee member
791 $a M.S.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1450793