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Surface modifications of a titanium ...

Crowder, Katherine Nicole.

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Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications./
作者:	Crowder, Katherine Nicole.
面頁冊數:	174 p.
附註:	Source: Dissertation Abstracts International, Volume: 68-12, Section: B, page: 8018.
Contained By:	Dissertation Abstracts International68-12B.
標題:	Chemistry, Inorganic. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3295294
ISBN:	9780549397366

Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications.
Crowder, Katherine Nicole.

Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications. - 174 p.

Source: Dissertation Abstracts International, Volume: 68-12, Section: B, page: 8018.

Thesis (Ph.D.)--Princeton University, 2008.

Titanium and its alloys, namely Ti-6Al-4V, are ideal materials for orthopedic implants; however, it remains a challenge to promote biointegration of these implants, which is essential for its long life and function within the body. A self-assembled monolayer of phosphonates (SAMP) can serve as a platform for further derivatizations that will covalently bond cell attractive biomolecules to the titanium surface in a stable manner. Bonding a cell attachment peptide, arginine-glycine-aspartic acid (RGD), to the titanium surface using the SAMP platform has been shown to increase osteoblast adhesion, spreading, and mineralization.

ISBN: 9780549397366Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications.
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245 1 0 $a Surface modifications of a titanium alloy: Translation from in vitro evaluations to in vivo implant applications.
300 $a 174 p.
500 $a Source: Dissertation Abstracts International, Volume: 68-12, Section: B, page: 8018.
502 $a Thesis (Ph.D.)--Princeton University, 2008.
520 $a Titanium and its alloys, namely Ti-6Al-4V, are ideal materials for orthopedic implants; however, it remains a challenge to promote biointegration of these implants, which is essential for its long life and function within the body. A self-assembled monolayer of phosphonates (SAMP) can serve as a platform for further derivatizations that will covalently bond cell attractive biomolecules to the titanium surface in a stable manner. Bonding a cell attachment peptide, arginine-glycine-aspartic acid (RGD), to the titanium surface using the SAMP platform has been shown to increase osteoblast adhesion, spreading, and mineralization.
520 $a Acyclic and cyclic RGD peptides were bound via the SAMP platform to Ti-6Al-4V to study the effect of peptide conformational presentation on cell adhesion in vitro; it has been proposed that cyclic forms of the peptide have a higher affinity for cell surface receptors. It was shown that acyclic RGD induces nearly equivalent cell adhesion and spreading as does cyclic RGD; it is postulated that this is due to the surfaces having a sufficiently high density of ligands so as to saturate the cell surface receptors.
520 $a The SAMP interface on Ti-6Al-4V was compared in an 8 week in vivo trial in a rat model to a reported thiolate interface on gold-coated titanium, both involving RGDC bound to the surface. The SAMP/RGD system had significantly greater new bone area at 2 weeks and new bone-to-implant contact at 8 weeks compared to the Au/RGD system.
520 $a A second, 16 week in vivo trial in rabbits compared the osteointegration of SAMP/RGD, phosphonate-terminated SAMP, and hydroxyapatite-coated quasi-porous implants. As evaluated by a pull-out test, the two SAMP coatings significantly increased the mechanical fixation of the implants. Bony ingrowth into the porous structures of the implants was promoted on the SAMP surfaces versus the hydroxyapatite coating.
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