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The design and fabrication of autono...

Swickrath, Michael J.

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The design and fabrication of autonomous polymer-based surface tension-confined microfluidic platforms.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The design and fabrication of autonomous polymer-based surface tension-confined microfluidic platforms./
Author:	Swickrath, Michael J.
Description:	171 p.
Notes:	Adviser: Gary E. Wnek.
Contained By:	Dissertation Abstracts International68-10B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3286194
ISBN:	9780549290940

The design and fabrication of autonomous polymer-based surface tension-confined microfluidic platforms.
Swickrath, Michael J.

The design and fabrication of autonomous polymer-based surface tension-confined microfluidic platforms. - 171 p.

Adviser: Gary E. Wnek.

Thesis (Ph.D.)--Case Western Reserve University, 2008.

The field of microfluidics, lab-on-a-chip technologies in particular, promises the capacity to automate sophisticated laboratory analyses into a platform that can be implemented by a user with minimal analytical experience. However, the fabrication methods traditionally employed to manufacture microfluidic devices are cost ineffective and time intensive. Consequently, current production techniques render exploiting this technology for clinical application problematic. This work describes an alternative fabrication technique to mitigate the aforementioned problems through surface tension-driven flow. Hydrophilic conduits are patterned on a variety of commodity polymeric substrates. The opposing two-dimensionally patterned devices are brought within close proximity for the fabrication of a parallel plate configured microfluidic device. The microfluidic platforms demonstrate the ability to facilitate spontaneous capillary pumping with a high degree of precision and minimal expenditure of fluid reagent.

ISBN: 9780549290940Subjects--Topical Terms:

1018428
Chemistry, Polymer.

The design and fabrication of autonomous polymer-based surface tension-confined microfluidic platforms.
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020 $a 9780549290940
035 $a (UMI)AAI3286194
035 $a AAI3286194
040 $a UMI $c UMI
100 1 $a Swickrath, Michael J. $3 1280746
245 1 4 $a The design and fabrication of autonomous polymer-based surface tension-confined microfluidic platforms.
300 $a 171 p.
500 $a Adviser: Gary E. Wnek.
500 $a Source: Dissertation Abstracts International, Volume: 68-10, Section: B, page: 6822.
502 $a Thesis (Ph.D.)--Case Western Reserve University, 2008.
520 $a The field of microfluidics, lab-on-a-chip technologies in particular, promises the capacity to automate sophisticated laboratory analyses into a platform that can be implemented by a user with minimal analytical experience. However, the fabrication methods traditionally employed to manufacture microfluidic devices are cost ineffective and time intensive. Consequently, current production techniques render exploiting this technology for clinical application problematic. This work describes an alternative fabrication technique to mitigate the aforementioned problems through surface tension-driven flow. Hydrophilic conduits are patterned on a variety of commodity polymeric substrates. The opposing two-dimensionally patterned devices are brought within close proximity for the fabrication of a parallel plate configured microfluidic device. The microfluidic platforms demonstrate the ability to facilitate spontaneous capillary pumping with a high degree of precision and minimal expenditure of fluid reagent.
520 $a In particular, several cost-effective fabrication procedures are illustrated as well as the capacity to manipulate fluids within the platforms utilizing volumes less than 20 total microliters. Furthermore, applications are demonstrated within the devices such as enzymatic-catalysis, on-chip urinalysis (i.e. glucose and protein detection), and micromixing; demonstrating the efficacy of the platform to automate fluid transport concomitantly with reaction processes. In addition, preliminary designs and protocols are suggested in the last chapter of this work for surface tension-confined devices capable of performing enzyme-linked immunosorbent assay (ELISA) and fluorescence resonance energy transfer (FRET).
520 $a Moreover, theoretical aspects of microfluidic flow are explored within this document including the physics of wetting and wetting energetics, factors influencing surface tension (and thereby the system driving force), the conservative level set method coupling two-phase flow and the Navier-Stokes equations, the expected velocity and Reynolds number of the advancing fluid front within the microfluidic platforms, calculating the curvature-based pressure jump across the advancing meniscus and non-dimensional numbers pertinent to capillary-driven microfluidic flow.
520 $a The extension of these results suggests that autonomous micro-analytical systems may be fabricated with limited rigor and mechanical components. Consequently, commercialization opportunities for this novel microfluidic platform are under consideration.
590 $a School code: 0042.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Chemical. $3 1018531
650 4 $a Physics, Fluid and Plasma. $3 1018402
690 $a 0495
690 $a 0542
690 $a 0759
710 2 $a Case Western Reserve University. $3 1017714
773 0 $t Dissertation Abstracts International $g 68-10B.
790 $a 0042
790 1 0 $a Wnek, Gary E., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3286194