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Glyconanobiotics: Novel carbohydrate...

Abeylath, Thotaha Wijayahewage Sampath Chrysantha.

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Glyconanobiotics: Novel carbohydrated nanoparticle polymers.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Glyconanobiotics: Novel carbohydrated nanoparticle polymers./
Author:	Abeylath, Thotaha Wijayahewage Sampath Chrysantha.
Description:	102 p.
Notes:	Adviser: Edward Turos.
Contained By:	Dissertation Abstracts International68-04B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3260037

Glyconanobiotics: Novel carbohydrated nanoparticle polymers.
Abeylath, Thotaha Wijayahewage Sampath Chrysantha.

Glyconanobiotics: Novel carbohydrated nanoparticle polymers. - 102 p.

Adviser: Edward Turos.

Thesis (Ph.D.)--University of South Florida, 2007.

Carbohydrates on the cell surface conjugates to proteins and lipids and participates in biological processes as glycoconjugates. Carbohydrate functionalized nanoparticles (glyconanoparticles) constitute a good bio-mimetic model of carbohydrate presentation at the cell surface and are currently centered on many glycobiological and biomedical applications. The most of the applications have been reported using gold glyconanoparticles. A brief review of gold glyconanoparticles and some of their applications will be discussed in Chapter I. Although metallic, semiconductor and magnetic glyconanoparticles have been reported, no polyacrylate glyconanoparticles have yet to be described.Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Glyconanobiotics: Novel carbohydrated nanoparticle polymers.
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035 $a (UMI)AAI3260037
035 $a AAI3260037
040 $a UMI $c UMI
100 1 $a Abeylath, Thotaha Wijayahewage Sampath Chrysantha. $3 1280701
245 1 0 $a Glyconanobiotics: Novel carbohydrated nanoparticle polymers.
300 $a 102 p.
500 $a Adviser: Edward Turos.
500 $a Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2385.
502 $a Thesis (Ph.D.)--University of South Florida, 2007.
520 $a Carbohydrates on the cell surface conjugates to proteins and lipids and participates in biological processes as glycoconjugates. Carbohydrate functionalized nanoparticles (glyconanoparticles) constitute a good bio-mimetic model of carbohydrate presentation at the cell surface and are currently centered on many glycobiological and biomedical applications. The most of the applications have been reported using gold glyconanoparticles. A brief review of gold glyconanoparticles and some of their applications will be discussed in Chapter I. Although metallic, semiconductor and magnetic glyconanoparticles have been reported, no polyacrylate glyconanoparticles have yet to be described.
520 $a Chapter II describes the first preparation of carbohydrate functionalized polymer nanoparticles by microemulsion polymerization and their characterization using scanning electron microscopy, dynamic light scattering and 1 H NMR spectroscopy. This methodology can generate a large number of furanose and pyranose nanoparticle derivatives with an average particle size of around 40 nm with the protected carbohydrate hydroxyl functionality as acetyl or dimethylacetal groups. Formation of larger glyconanoparticles of around 80 nm with 3-O-acryloyl-D-glucose and 5-O -acryloyl-1-methoxy-beta-D-ribofuranose reveals the influence of free hydroxyl groups in the monomer on the particle size during polymerization, a feature which is also apparently dependent on the amount of carbohydrate in the matrix.
520 $a Preparation of glyconanoparticle antibiotics, or glyconanobiotics , by microemulsion of antibiotic-conjugated carbohydrate monomers demonstrates for the first time the use of glyconanoparticles as drug delivery vehicles in Chapter III. The conjugation of an acrylated hydrophobic carbohydrate moiety to the lipophilic antibiotic makes it even more lipophilic and suitable as a co-monomer in microemulsion polymerization with styrene/butyl acrylate. Novel carbohydrate-based acrylated acyl chlorides synthesized from glucose afford antibiotic monomers with enhanced lipophilicity in a one step procedure. These drug monomers and the corresponding glyconanobiotics prepared by conjugating antibiotics such as N-thiolated-beta-lactam, ciprofloxacin, and penicillin shows biological activity against S. aureus, MRSA and B. anthracis microbes.
520 $a Glyconanoparticles prepared by microemulsion polymerization of 3- O-acryloyl-D-glucose and styrene/butyl acrylate may be potentially used as recognition units in carbohydrate ligand mediated targeted drug delivery. The binding capability of the surface-exposed carbohydrates on the nanoparticle can be detected by fluorescence spectroscopy utilizing pyranine and 4,4'- N,N-bis(benzyl-2-boronic acid)-bipyridinium dibromide as described in Chapter IV.
590 $a School code: 0206.
650 4 $a Chemistry, Polymer. $3 1018428
690 $a 0495
710 2 $a University of South Florida. $3 1020446
773 0 $t Dissertation Abstracts International $g 68-04B.
790 $a 0206
790 1 0 $a Turos, Edward, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3260037