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Regulation of human MUC7 mucin gene ...

Fan, Hao.

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Regulation of human MUC7 mucin gene expression by cigarette smoke and Pseudomonas aeruginosa lipopolysaccharide in human airway epithelial cells and in MUC7 transgenic mice.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Regulation of human MUC7 mucin gene expression by cigarette smoke and Pseudomonas aeruginosa lipopolysaccharide in human airway epithelial cells and in MUC7 transgenic mice./
Author:	Fan, Hao.
Description:	57 p.
Notes:	Advisers: Libuse A. Bobek; Frank A. Scannapieco.
Contained By:	Masters Abstracts International46-02.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1446256
ISBN:	9780549173342

Regulation of human MUC7 mucin gene expression by cigarette smoke and Pseudomonas aeruginosa lipopolysaccharide in human airway epithelial cells and in MUC7 transgenic mice.
Fan, Hao.

Regulation of human MUC7 mucin gene expression by cigarette smoke and Pseudomonas aeruginosa lipopolysaccharide in human airway epithelial cells and in MUC7 transgenic mice. - 57 p.

Advisers: Libuse A. Bobek; Frank A. Scannapieco.

Thesis (M.S.)--State University of New York at Buffalo, 2007.

MUC7 gene encodes a small-mucin-glycoprotein that functions in lubricating/protecting epithelial surface of the human oral cavity/respiratory tract.

ISBN: 9780549173342Subjects--Topical Terms:

1017734
Biology, Microbiology.

Regulation of human MUC7 mucin gene expression by cigarette smoke and Pseudomonas aeruginosa lipopolysaccharide in human airway epithelial cells and in MUC7 transgenic mice.
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020 $a 9780549173342
035 $a (UMI)AAI1446256
035 $a AAI1446256
040 $a UMI $c UMI
100 1 $a Fan, Hao. $3 1280025
245 1 0 $a Regulation of human MUC7 mucin gene expression by cigarette smoke and Pseudomonas aeruginosa lipopolysaccharide in human airway epithelial cells and in MUC7 transgenic mice.
300 $a 57 p.
500 $a Advisers: Libuse A. Bobek; Frank A. Scannapieco.
500 $a Source: Masters Abstracts International, Volume: 46-02, page: 0852.
502 $a Thesis (M.S.)--State University of New York at Buffalo, 2007.
520 $a MUC7 gene encodes a small-mucin-glycoprotein that functions in lubricating/protecting epithelial surface of the human oral cavity/respiratory tract.
520 $a To increase the understanding of the regulation of MUC7 expression, this study evaluated the effect of pathogenic factors, cigarette smoke and Pseudomonas aeruginosa LPS, on MUC7 expression in human lung carcinoma cell-line NCI-H292 (in-vitro) and MUC7 transgenic mice ( in-vivo). Expression of human MUC5AC, or mouse Muc5ac and Muc10 (MUC7 ortholog) was assessed for comparative purposes.
520 $a The in-vitro result showed that with LPS or cigarette smoke extract (CSE) alone, there was a statistically significant increase in the transcription (by quantitative real-time RT-PCR) of MUC7 only with 1%CSE (3.2-fold) and of MUC5AC only with LPS (6-fold). The combination of CSE/LPS resulted in 3.2-4.4-fold and 13-22-fold increase of MUC7 and MUC5AC transcripts, respectively. However, the mucin glycoprotein levels (by ELISA) increased only by 1.3-1.5-fold. In vivo, the smoke/LPS treatment of mice resulted in variable increase of mucins on transcriptional and glycoprotein level (immunohistochemistry) in trachea and lung tissues.
590 $a School code: 0656.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Molecular. $3 1017719
690 $a 0307
690 $a 0410
710 2 $a State University of New York at Buffalo. $b Oral Biology. $3 1280026
773 0 $t Masters Abstracts International $g 46-02.
790 $a 0656
790 1 0 $a Bobek, Libuse A., $e advisor
790 1 0 $a Scannapieco, Frank A., $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1446256