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Label-free sensing with semiconducti...

Stern, Eric.

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Label-free sensing with semiconducting nanowires.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Label-free sensing with semiconducting nanowires./
Author:	Stern, Eric.
Description:	214 p.
Notes:	Adviser: Mark A. Reed.
Contained By:	Dissertation Abstracts International68-06B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3267367
ISBN:	9780549067276

Label-free sensing with semiconducting nanowires.
Stern, Eric.

Label-free sensing with semiconducting nanowires. - 214 p.

Adviser: Mark A. Reed.

Thesis (Ph.D.)--Yale University, 2007.

Nanoscale electronic devices have the potential to achieve exquisite sensitivity as sensors for the direct detection of molecular interactions, thereby decreasing diagnostics costs and enabling previously impossible sensing in disparate field environments. Semiconducting nanowire-field effect transistors (NW-FETs) hold particular promise, though contemporary NW approaches are inadequate for realistic applications. We present here a novel approach using complementary metal-oxide-semiconductor (CMOS) technology that has not only achieved unprecedented sensitivity, but simultaneously facilitates system-scale integration of nanosensors for the first time. This approach enables a wide range of label-free biochemical and macromolecule sensing applications, including cell type discrimination through the monitoring of live, stimulus-induced cellular response, and specific protein and complementary DNA recognition assays. An important achievement is the introduction of real-time, unlabeled detection capability, allowing for fundamental studies of cellular activation, and specific macromolecule interactions at concentrations (<femtomolar) orders of magnitude lower than other commonly available techniques.

ISBN: 9780549067276Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Label-free sensing with semiconducting nanowires.
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020 $a 9780549067276
035 $a (UMI)AAI3267367
035 $a AAI3267367
040 $a UMI $c UMI
100 1 $a Stern, Eric. $3 1278860
245 1 0 $a Label-free sensing with semiconducting nanowires.
300 $a 214 p.
500 $a Adviser: Mark A. Reed.
500 $a Source: Dissertation Abstracts International, Volume: 68-06, Section: B, page: 3945.
502 $a Thesis (Ph.D.)--Yale University, 2007.
520 $a Nanoscale electronic devices have the potential to achieve exquisite sensitivity as sensors for the direct detection of molecular interactions, thereby decreasing diagnostics costs and enabling previously impossible sensing in disparate field environments. Semiconducting nanowire-field effect transistors (NW-FETs) hold particular promise, though contemporary NW approaches are inadequate for realistic applications. We present here a novel approach using complementary metal-oxide-semiconductor (CMOS) technology that has not only achieved unprecedented sensitivity, but simultaneously facilitates system-scale integration of nanosensors for the first time. This approach enables a wide range of label-free biochemical and macromolecule sensing applications, including cell type discrimination through the monitoring of live, stimulus-induced cellular response, and specific protein and complementary DNA recognition assays. An important achievement is the introduction of real-time, unlabeled detection capability, allowing for fundamental studies of cellular activation, and specific macromolecule interactions at concentrations (<femtomolar) orders of magnitude lower than other commonly available techniques.
590 $a School code: 0265.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Electronics and Electrical. $3 626636
690 $a 0541
690 $a 0544
710 2 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 68-06B.
790 $a 0265
790 1 0 $a Reed, Mark A., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3267367