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The flow-mediated dilation response ...

Harris, Ryan A.

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The flow-mediated dilation response to acute exercise in overweight men.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The flow-mediated dilation response to acute exercise in overweight men./
Author:	Harris, Ryan A.
Description:	301 p.
Notes:	Adviser: Janet P. Wallace.
Contained By:	Dissertation Abstracts International68-07B.
Subject:	Biology, Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3274243
ISBN:	9780549151029

The flow-mediated dilation response to acute exercise in overweight men.
Harris, Ryan A.

The flow-mediated dilation response to acute exercise in overweight men. - 301 p.

Adviser: Janet P. Wallace.

Thesis (Ph.D.)--Indiana University, 2007.

This research was supported by the Gatorade Sport Science Institute and Indiana University HPER Research Grant-in-Aids.

ISBN: 9780549151029Subjects--Topical Terms:

1017816
Biology, Physiology.

The flow-mediated dilation response to acute exercise in overweight men.
LDR:03115nam 2200313 a 45 001 955091
005 20110622
008 110622s2007 eng d
020 $a 9780549151029
035 $a (UMI)AAI3274243
035 $a AAI3274243
040 $a UMI $c UMI
100 1 $a Harris, Ryan A. $3 1278551
245 1 4 $a The flow-mediated dilation response to acute exercise in overweight men.
300 $a 301 p.
500 $a Adviser: Janet P. Wallace.
500 $a Source: Dissertation Abstracts International, Volume: 68-07, Section: B, page: 4314.
502 $a Thesis (Ph.D.)--Indiana University, 2007.
520 $a This research was supported by the Gatorade Sport Science Institute and Indiana University HPER Research Grant-in-Aids.
520 $a Introduction. Inflammation has been found to play a role in the etiology of coronary heart disease as well as induce endothelial dysfunction. Brachial artery flowmediated dilation (FMD) is a measure of nitric oxide dependent vasodilation and represents a non-invasive measurement of endothelial function. The aim of the present study was to (1) investigate the interaction of inflammatory biomarkers on the FMD response to acute exercise in overweight men and (2) determine if FMD following moderate intensity acute exercise is reproducible.
520 $a Methods. Sixteen overweight men ages 46-68 years were classified as either being active or inactive. Subjects performed three acute exercise treatments (25%, 50%, and 75% VO2peak), separated by at least two days apart. The 50% intensity was repeated in 9 subjects to investigate FMD reproducibility in response to acute exercise. Following the initial insertion of a venous catheter, brachial artery Flow-Mediated Dilation (FMD) and subsequent blood samples were taken pre exercise and every hour for three hours thereafter.
520 $a Results. The active group displayed a 24% increase (p=.034) in FMD following acute exercise compared to a 32% decrease (p=.010) in FMD observed in the inactive group. Both groups exhibited an elevated concentration of IL-6 following moderate (50% VO2) and high (75% VO2) intensity acute exercise (p<.001 and p<.001, respectively), whereas no change (p=.669) in IL-6 following low intensity (25% VO2) exercise in either group was observed. No differences in TNF-alpha were observed between groups (p=.433) or in response to acute exercise (p=.584). A significant FMD correlation (r = 0.531; p=.008) following exercise between trial 1 and trial 2 was found.
520 $a Conclusion. FMD following exercise appears to be as reproducible as resting controlled conditions. In addition, the FMD response to acute exercise is enhanced in overweight active men when compared to their inactive counterparts; however, inflammation did not provide insight into the physiological mechanisms associated with the improvement of FMD.
590 $a School code: 0093.
650 4 $a Biology, Physiology. $3 1017816
690 $a 0719
710 2 $a Indiana University. $b School of Health, Physical Education and Recreation. $3 1018026
773 0 $t Dissertation Abstracts International $g 68-07B.
790 $a 0093
790 1 0 $a Wallace, Janet P., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3274243