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Isolation, structure elucidation, an...

Pugh, Nirmal Derek Ceri.

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Isolation, structure elucidation, and biological characterization of immunostimulants from dietary supplements and natural products.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Isolation, structure elucidation, and biological characterization of immunostimulants from dietary supplements and natural products./
作者:	Pugh, Nirmal Derek Ceri.
面頁冊數:	184 p.
附註:	Adviser: David S. Pasco.
Contained By:	Dissertation Abstracts International65-12B.
標題:	Chemistry, Organic. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3159512
ISBN:	9780496925568

Isolation, structure elucidation, and biological characterization of immunostimulants from dietary supplements and natural products.
Pugh, Nirmal Derek Ceri.

Isolation, structure elucidation, and biological characterization of immunostimulants from dietary supplements and natural products. - 184 p.

Adviser: David S. Pasco.

Thesis (Ph.D.)--The University of Mississippi, 2001.

Some of the monocyte activating substances characterized in this work could be developed for commercial use as both dietary supplement preparations for general immune enhancement as well as for new pharmaceuticals for use in immunotherapy.

ISBN: 9780496925568Subjects--Topical Terms:

516206
Chemistry, Organic.

Isolation, structure elucidation, and biological characterization of immunostimulants from dietary supplements and natural products.
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245 1 0 $a Isolation, structure elucidation, and biological characterization of immunostimulants from dietary supplements and natural products.
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500 $a Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6308.
502 $a Thesis (Ph.D.)--The University of Mississippi, 2001.
520 $a Some of the monocyte activating substances characterized in this work could be developed for commercial use as both dietary supplement preparations for general immune enhancement as well as for new pharmaceuticals for use in immunotherapy.
520 $a This dissertation represents an effort to characterize immunostimulatory (monocyte/macrophage enhancing) compounds from the following dietary supplements and natural products: food-grade microalgae, Aloe barbadensis, Astragalus species, Echinacea species, Podophyllum species, and marine/aquatic algae. A transcription-factor based reporter gene assay measuring activation of nuclear factor kappa B (NF-kappa B) in THP-1 cells was used to evaluate monocyte activation. A secondary bioassay detecting induction of mRNAs for interleukin-1 beta and tumor necrosis factor alpha was used to confirm immunostimulatory activity.
520 $a An aqueous extract from food-grade Aphanizomenon flos-aquae microalgae contained monocyte-activating properties that were transduced through pathways similar to LPS-dependent activation. The compound responsible for this activity is a new high molecular weight polysaccharide, called Immunon, that can be recovered with a 5% yield and an EC50 value for NF-kappa B activation of 20ng/mL. Immunostimulatory polysaccharide preparations were also isolated from two other food-grade microalgaes, Spirulina platensis and Chlorella pyrenoidosa.
520 $a Immunostimulatory properties of Aloe vera juice were compared with acemannan, a carbohydrate component from aloe purported to have immune enhancing effects. Results demonstrated that acemannan is a weak activator of monocytes and that its low activity is due to the presence of a new, potent polysaccharide named Aloeride which is present in trace amounts in acemannan preparations.
520 $a Crude non-polar extracts from Echinacea species were inactive for monocyte activation. However, fractionation resulted in two regions of activity, immunosuppressive and immunostimulatory. The immunostimulatory fractions both enhanced LPS-induced macrophage activation and also acted as independent activators. From Astragalus species 19 cycloartane-type triterpene glycosides were analyzed and all were inactive except astragaloside I. Podophyllotoxin and specific analogs did not function as independent activators, but instead selectively enhanced or suppressed LPS-induced gene expression. Several hundred extracts of marine/aquatic algae were also evaluated for monocyte activation. Active extracts were fractionated to obtain purified substances with potent immunostimulatory activity (EC50 values of 10ng/mL).
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650 4 $a Health Sciences, Immunology. $3 1017716
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