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Development of ocular drug delivery ...

Haesslein, Andrea.

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Development of ocular drug delivery systems using biodegradable polymers.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Development of ocular drug delivery systems using biodegradable polymers./
作者:	Haesslein, Andrea.
面頁冊數:	152 p.
附註:	Adviser: Antonios G. Mikos.
Contained By:	Masters Abstracts International45-04.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1441824

Development of ocular drug delivery systems using biodegradable polymers.
Haesslein, Andrea.

Development of ocular drug delivery systems using biodegradable polymers. - 152 p.

Adviser: Antonios G. Mikos.

Thesis (M.S.)--Rice University, 2007.

We found that prefabricated, photo-crosslinked PPF/PNVP matrices represent suitable, controllable release systems for different drugs. Furthermore, coaxial electrospinning is a promising technique to generate scaffolds for drug delivery.Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Development of ocular drug delivery systems using biodegradable polymers.
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100 1 $a Haesslein, Andrea. $3 1269536
245 1 0 $a Development of ocular drug delivery systems using biodegradable polymers.
300 $a 152 p.
500 $a Adviser: Antonios G. Mikos.
500 $a Source: Masters Abstracts International, Volume: 45-04, page: 2022.
502 $a Thesis (M.S.)--Rice University, 2007.
520 $a We found that prefabricated, photo-crosslinked PPF/PNVP matrices represent suitable, controllable release systems for different drugs. Furthermore, coaxial electrospinning is a promising technique to generate scaffolds for drug delivery.
520 $a The delivery of drugs plays an important role in the treatment of ocular diseases. In this thesis, biocompatible, biodegradable materials such as poly(propylene fumarate) (PPF) and poly(lactic-co-glycolic) (PLGA) were used to prepare delivery systems. PPF together with N-vinyl pyrrolidone (NVP) was photo-crosslinked to generate monolithic polymer rods, which were loaded with either acetazolamide (AZ), dichlorphenamide (DP) or timolol maleate (TM). The release kinetics and structural properties were determined as well as the in vivo degradation. Further studies were performed to examine the influence of PPF molecular weight and the ratio of PPF/PNVP on the release kinetics. In addition, a coaxial electrospinning setup was developed to fabricate PLGA fiber networks as a delivery system.
590 $a School code: 0187.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Ophthalmology. $3 1019445
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790 $a 0187
790 1 0 $a Mikos, Antonios G., $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1441824