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Preparation and surface characteriza...

Langowski, Bryan Alfred.

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Preparation and surface characterization of plasma-treated and biomolecular-micropatterned polymer substrates.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Preparation and surface characterization of plasma-treated and biomolecular-micropatterned polymer substrates./
作者:	Langowski, Bryan Alfred.
面頁冊數:	194 p.
附註:	Adviser: Kathryn E. Uhrich.
Contained By:	Dissertation Abstracts International68-08B.
標題:	Chemistry, Polymer. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3277302
ISBN:	9780549192602

Preparation and surface characterization of plasma-treated and biomolecular-micropatterned polymer substrates.
Langowski, Bryan Alfred.

Preparation and surface characterization of plasma-treated and biomolecular-micropatterned polymer substrates. - 194 p.

Adviser: Kathryn E. Uhrich.

Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick, 2007.

A micropatterning process creates distinct microscale domains on substrate surfaces that differ from the surfaces' original chemical/physical properties. Numerous micropatterning methods exist, each having relative advantages and disadvantages in terms of cost, ease, reproducibility, and versatility. Polymeric surfaces micropatterned with biomolecules have many applications, but are specifically utilized in tissue engineering as cell scaffolds that attempt to controlled tissue generation in vivo and ex vivo. As the physical and chemical cues presented by micropatterned substrates control resulting cellular behavior, characterization of these cues via surface-sensitive analytical techniques is essential in developing cell scaffolds that mimic complex in vivo physicochemical environments.

ISBN: 9780549192602Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Preparation and surface characterization of plasma-treated and biomolecular-micropatterned polymer substrates.
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245 1 0 $a Preparation and surface characterization of plasma-treated and biomolecular-micropatterned polymer substrates.
300 $a 194 p.
500 $a Adviser: Kathryn E. Uhrich.
500 $a Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5266.
502 $a Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick, 2007.
520 $a A micropatterning process creates distinct microscale domains on substrate surfaces that differ from the surfaces' original chemical/physical properties. Numerous micropatterning methods exist, each having relative advantages and disadvantages in terms of cost, ease, reproducibility, and versatility. Polymeric surfaces micropatterned with biomolecules have many applications, but are specifically utilized in tissue engineering as cell scaffolds that attempt to controlled tissue generation in vivo and ex vivo. As the physical and chemical cues presented by micropatterned substrates control resulting cellular behavior, characterization of these cues via surface-sensitive analytical techniques is essential in developing cell scaffolds that mimic complex in vivo physicochemical environments.
520 $a The initial focus of this thesis is the chemical and physical characterization of plasma-treated, microcontact-printed (muCP) polymeric substrates used to direct nerve cell behavior. Unmodified and oxygen plasma-treated poly(methyl methacrylate) (PMMA) substrates were analyzed by surface sensitive techniques to monitor plasma-induced chemical and physical modifications. Additionally, protein-micropattern homogeneity and size were microscopically evaluated. Lastly, poly(dimethylsiloxane) (PDMS) stamps and contaminated PMMA substrates were characterized by spectroscopic and microscopic methods to identify a contamination source during microcontact printing.
520 $a The final focus of this thesis is the development of microscale plasma-initiated patterning (muPIP) as a versatile, reproducible micropatterning method. Using muPIP, polymeric substrates were micropatterned with several biologically relevant inks. Polymeric substrates were characterized following muPIP by surface-sensitive techniques to identify the technique's underlying physical and chemical bases. In addition, neural stem cell response to muPIP-generated laminin micropatterns was microscopically and biologically evaluated. Finally, enhanced versatility of muPIP in generating microscale poly-L-lysine gradients was demonstrated.
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