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Genetic variations in calcium and vi...

Dong, Linda M.

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Genetic variations in calcium and vitamin D related genes and colon cancer risk.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Genetic variations in calcium and vitamin D related genes and colon cancer risk./
Author:	Dong, Linda M.
Description:	124 p.
Notes:	Adviser: Ulrike Peters.
Contained By:	Dissertation Abstracts International68-08B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3275864
ISBN:	9780549160908

Genetic variations in calcium and vitamin D related genes and colon cancer risk.
Dong, Linda M.

Genetic variations in calcium and vitamin D related genes and colon cancer risk. - 124 p.

Adviser: Ulrike Peters.

Thesis (Ph.D.)--University of Washington, 2007.

Within the last few decades, a remarkable amount of effort has been focused on identifying genetic markers that identify increased susceptibility to cancer. A review, presented here, of all published meta- and pooled analyses evaluating candidate gene-variant/cancer associations suggests that the strongest variants associated with cancer susceptibility at this time are Phase II enzymes. Phase II enzymes demonstrated highly statistically significant associations with leukemia, bladder, colorectal, and head and neck cancer. Attention in a majority of genetic association studies has primarily been on single candidate polymorphisms. Although the choice of candidate polymorphisms is often well justified, this approach is less than comprehensive and does not fully assess the relationship between genetic variation and cancer risk.

ISBN: 9780549160908Subjects--Topical Terms:

1017730
Biology, Genetics.

Genetic variations in calcium and vitamin D related genes and colon cancer risk.
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100 1 $a Dong, Linda M. $3 1269345
245 1 0 $a Genetic variations in calcium and vitamin D related genes and colon cancer risk.
300 $a 124 p.
500 $a Adviser: Ulrike Peters.
500 $a Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5110.
502 $a Thesis (Ph.D.)--University of Washington, 2007.
520 $a Within the last few decades, a remarkable amount of effort has been focused on identifying genetic markers that identify increased susceptibility to cancer. A review, presented here, of all published meta- and pooled analyses evaluating candidate gene-variant/cancer associations suggests that the strongest variants associated with cancer susceptibility at this time are Phase II enzymes. Phase II enzymes demonstrated highly statistically significant associations with leukemia, bladder, colorectal, and head and neck cancer. Attention in a majority of genetic association studies has primarily been on single candidate polymorphisms. Although the choice of candidate polymorphisms is often well justified, this approach is less than comprehensive and does not fully assess the relationship between genetic variation and cancer risk.
520 $a Results from experimental and epidemiologic studies have provided evidence that high calcium and vitamin D intake are associated with decreased colon cancer risk. However, the primary focus of studies investigating the calcium/vitamin D pathway has been on the vitamin D receptor (VDR), with very few data available for other candidate genes in this pathway, such as the calcium sensing receptor (CASR) and vitamin D activating enzyme 1-alpha hydroxylase (CYP27B1) and the vitamin D deactivating enzyme 24-alpha hydroxylase (CYP24A1). Using a multi-center population-based case-control study of 1,616 cases and 1,949 controls, I comprehensively assessed the genetic variation of CASR, CYP27B1 and CYP24A1 in relation to colon cancer risk. I also examined whether polymorphisms in these genes modified associations with dietary calcium, vitamin D, and UV-weighted sun exposure, as well as VDR polymorphisms.
520 $a Overall, I did not observe an association between any genotypes or haplotypes in CASR, CYP27B1, and CYP24A1 and colon cancer risk. However, stratification by anatomic subsite revealed statistically significant associations for three polymorphisms in CASR with risk of proximal colon cancer and three polymorphisms in CYP24A1 with risk of distal colon cancer.
590 $a School code: 0250.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Health Sciences, Epidemiology. $3 1019544
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791 $a Ph.D.
792 $a 2007
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