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Role of endothelin and chemokine sig...

Nair, Sreelaja Sreedharan.

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Role of endothelin and chemokine signaling in morphogenesis of the zebrafish craniofacial skeleton and endoderm.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Role of endothelin and chemokine signaling in morphogenesis of the zebrafish craniofacial skeleton and endoderm./
作者:	Nair, Sreelaja Sreedharan.
面頁冊數:	191 p.
附註:	Adviser: Thomas F. Schilling.
Contained By:	Dissertation Abstracts International68-12B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3293067
ISBN:	9780549369233

Role of endothelin and chemokine signaling in morphogenesis of the zebrafish craniofacial skeleton and endoderm.
Nair, Sreelaja Sreedharan.

Role of endothelin and chemokine signaling in morphogenesis of the zebrafish craniofacial skeleton and endoderm. - 191 p.

Adviser: Thomas F. Schilling.

Thesis (Ph.D.)--University of California, Irvine, 2006.

Embryogenesis involves sequential interactions between cells, which transform an amorphous mass of undifferentiated cells into a three-dimensional organism containing a vast array of different cell types. For my thesis work I have focused on how cell fates are established in two complex organ systems, the craniofacial skeleton and the gut, using a genetic approach in zebrafish. Tissue interactions and signaling molecules that control morphogenesis of these organs are remarkably conserved between zebrafish and humans, providing us with a genetically tractable system to understand the underlying causes of many congenital craniofacial and digestive disorders.

ISBN: 9780549369233Subjects--Topical Terms:

1017730
Biology, Genetics.

Role of endothelin and chemokine signaling in morphogenesis of the zebrafish craniofacial skeleton and endoderm.
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520 $a Embryogenesis involves sequential interactions between cells, which transform an amorphous mass of undifferentiated cells into a three-dimensional organism containing a vast array of different cell types. For my thesis work I have focused on how cell fates are established in two complex organ systems, the craniofacial skeleton and the gut, using a genetic approach in zebrafish. Tissue interactions and signaling molecules that control morphogenesis of these organs are remarkably conserved between zebrafish and humans, providing us with a genetically tractable system to understand the underlying causes of many congenital craniofacial and digestive disorders.
520 $a Every organ in the body is polarized relative to the anterior-posterior (A-P) and dorsal-ventral (D-V) body axes. Endothelin-1 (Edn1) is a small conserved peptide required for establishing the D-V polarity of the jaw. I have isolated zebrafish orthologues of the Endothelin receptor type A (EdnrA) and shown that they are indispensable for formation of the lower jaw skeleton. My analyses of tissue mosaics with Edn1-deficient cells established a crucial source of this signal in the facial ectoderm that patterns migrating cranial neural crest cells that form the jaw, and suggested that Edn1 acts through an autoregulatory loop within the ectoderm that maintains Edn1 and induces joint formation. Additional work presented in my dissertation demonstrated requirements for two other conserved transcription factors, TFAP2alpha and Tbx1, in craniofacial development. Tbx1, in particular, appears to control morphogenesis of the endoderm and expression of Edn1 for patterning of the jaw, while TFAP2alpha acts directly within skeletogenic neural crest cells. These results illustrate the combination of intrinsic and extrinsic factors that influence cell fates within the skeleton.
520 $a For the signaling events discussed above to occur, the progenitors of these tissues must undergo extensive cellular rearrangements during gastrulation. My research demonstrates for the first time that interactions between a chemokine CXCL12b and its receptor CXCR4a choreographs the movements of endoderm during gastrulation. We propose a novel "chemokine tether" model that is in place at the onset of gastrulation, which limits migratory distances of endoderm progenitors, thereby ensuring correct spatial organization of this germ layer.
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