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Effects of aging and moderate calori...

Sitzmann, Brandon Dale.

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Effects of aging and moderate calorie restriction on the reproductive axis of the male rhesus macaque (Macaca mulatta).

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effects of aging and moderate calorie restriction on the reproductive axis of the male rhesus macaque (Macaca mulatta)./
Author:	Sitzmann, Brandon Dale.
Description:	340 p.
Notes:	Adviser: Mary Ann Ottinger.
Contained By:	Dissertation Abstracts International68-04B.
Subject:	Biology, Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3260394

Effects of aging and moderate calorie restriction on the reproductive axis of the male rhesus macaque (Macaca mulatta).
Sitzmann, Brandon Dale.

Effects of aging and moderate calorie restriction on the reproductive axis of the male rhesus macaque (Macaca mulatta). - 340 p.

Adviser: Mary Ann Ottinger.

Thesis (Ph.D.)--University of Maryland, College Park, 2007.

Calorie restriction (CR) has been established as the only non-genetic method of altering longevity and attenuating biological changes associated with aging. This nutritional paradigm has been effective in nematodes, flies, rodents, dogs and possibly non-human primates. Its long history notwithstanding, little is known regarding the exact mechanism(s) of CR action or its potential impact on the hypothalamic-pituitary-gonadal (HPG) axis. The objectives of this project were to: (1) analyze neuroendocrine changes to the HPG axis that occur with aging and (2) evaluate the effects of moderate CR on reproductive function in male rhesus macaques.Subjects--Topical Terms:

1017816
Biology, Physiology.

Effects of aging and moderate calorie restriction on the reproductive axis of the male rhesus macaque (Macaca mulatta).
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005 20110520
008 110520s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI3260394
035 $a AAI3260394
040 $a UMI $c UMI
100 1 $a Sitzmann, Brandon Dale. $3 1267697
245 1 0 $a Effects of aging and moderate calorie restriction on the reproductive axis of the male rhesus macaque (Macaca mulatta).
300 $a 340 p.
500 $a Adviser: Mary Ann Ottinger.
500 $a Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2143.
502 $a Thesis (Ph.D.)--University of Maryland, College Park, 2007.
520 $a Calorie restriction (CR) has been established as the only non-genetic method of altering longevity and attenuating biological changes associated with aging. This nutritional paradigm has been effective in nematodes, flies, rodents, dogs and possibly non-human primates. Its long history notwithstanding, little is known regarding the exact mechanism(s) of CR action or its potential impact on the hypothalamic-pituitary-gonadal (HPG) axis. The objectives of this project were to: (1) analyze neuroendocrine changes to the HPG axis that occur with aging and (2) evaluate the effects of moderate CR on reproductive function in male rhesus macaques.
520 $a Pituitary gene expression profiling, semi-quantitative RT-PCR (sqRT-PCR) and immunohistochemistry showed circadian clock mechanism components present in three age categories of macaques, demonstrated age differences in expression for Per2, indicated differential expression of Per2 and Bmal1 at opposing time points and revealed daily rhythmic expression of REV-ERBalpha protein. These data indicate the ability of the macaque pituitary to express core-clock genes, their protein products, and to do so in a 24-hour rhythm.
520 $a Young Adult CON and CR pituitary gene expression profiles detected potential differential expression in <150 probesets. A decline in TSHR and CGA was detected in CR macaques as measured by sqRT-PCR. Other genes investigated showed no diet-induced changes.
520 $a Young Adult CON and CR testicular gene expression profiles detected potential differential expression in <300 probesets although mRNA expression was not altered based on sqRT-PCR and real-time RT-PCR. Age-related and/or diet-induced changes in HSD17beta3, INSL3, CSNK1E and CGA were observed in a separate experiment with CGA in Old Adult CR subjects returning to youthful levels.
520 $a Semen samples were collected from Young Adult CON and CR macaques. Normal spermiogram measures, ZP-binding, AR assay and SCSARTM were conducted and indicated no differences between CON and CR-treated animals. Both groups exhibited similar daily testosterone profiles with no differences in mean or maximum levels; however, daily minimum testosterone levels were lower in CON animals.
520 $a It appears that moderate CR had limited impact on neuroendocrine or reproductive function in male rhesus macaques based on our selected endpoints. Thus, advantageous CR health benefits can be achieved without obvious negative consequences to the HPG axis.
590 $a School code: 0117.
650 4 $a Biology, Physiology. $3 1017816
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0570
690 $a 0719
710 2 $a University of Maryland, College Park. $b Animal Sciences. $3 1023474
773 0 $t Dissertation Abstracts International $g 68-04B.
790 $a 0117
790 1 0 $a Ottinger, Mary Ann, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3260394