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Healing response of knee ligaments t...

Jensen, Kristina Tibesar.

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Healing response of knee ligaments to prolotherapy in a rat model.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Healing response of knee ligaments to prolotherapy in a rat model./
Author:	Jensen, Kristina Tibesar.
Description:	87 p.
Notes:	Adviser: Ray Vanderby, Jr.
Contained By:	Dissertation Abstracts International67-06B.
Subject:	Biology, Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222876
ISBN:	9780542753749

Healing response of knee ligaments to prolotherapy in a rat model.
Jensen, Kristina Tibesar.

Healing response of knee ligaments to prolotherapy in a rat model. - 87 p.

Adviser: Ray Vanderby, Jr.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2006.

Prolotherapy is an alternative medicine technique used to treat joint pain. A series of injections of irritant solutions are hypothesized by proponents to cause inflammation, reenergize healing, tighten lax ligaments and, thereby, reduce pain. However, no study has shown that inflammation and subsequent biomechanical effects occur.

ISBN: 9780542753749Subjects--Topical Terms:

1017816
Biology, Physiology.

Healing response of knee ligaments to prolotherapy in a rat model.
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020 $a 9780542753749
035 $a (UMI)AAI3222876
035 $a AAI3222876
040 $a UMI $c UMI
100 1 $a Jensen, Kristina Tibesar. $3 1267675
245 1 0 $a Healing response of knee ligaments to prolotherapy in a rat model.
300 $a 87 p.
500 $a Adviser: Ray Vanderby, Jr.
500 $a Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3269.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2006.
520 $a Prolotherapy is an alternative medicine technique used to treat joint pain. A series of injections of irritant solutions are hypothesized by proponents to cause inflammation, reenergize healing, tighten lax ligaments and, thereby, reduce pain. However, no study has shown that inflammation and subsequent biomechanical effects occur.
520 $a Study 1. Medial collateral ligaments (MCLs) of 44 rats were injected at tibial and femoral insertions. Immunohistochemistry was utilized to determine the inflammatory response at three locations (tibial and femoral insertions and midsubstance) 6, 24, and 72 hours after dextrose injection compared to saline and no-injection controls (n=4). At 24 hours, sodium morrhuate, P2G, and needle stick control were also investigated. At 6 hours, dextrose and saline injected ligaments had increases in macrophages at both insertions. At 24 hours, sodium morrhuate, P2G, saline, and needle stick had increases in neutrophils at the tibia and/or midsubstance, and dextrose, sodium morrhuate, and needle stick had increases in macrophages at the femur compared to no injection. At 72 hours, inflammation was resolved.
520 $a Study 2. Twenty-four rats were bilaterally MCL stretch-injured and the induced laxity measured. After two weeks of healing, MCLs were injected twice, one week apart with dextrose, saline control, or no injection control. Seven uninjured rats were additional controls. Two weeks after the second injection, ligament laxity and pull-to-failure tests (n=8) and TEM (n=3) were performed. Consistent laxity was created and was not altered by dextrose injections. Failure force was similar for all groups. Cross-sectional area was 30 and 90% increased with dextrose over saline and uninjured controls, respectively. Collagen fibril diameter decreased in injured ligaments compared to uninjured controls. Collagen fibril density decreased by 31% in injured ligaments compared to uninjured controls. Collagen fibril diameter and density were not altered by injection.
520 $a Conclusions. Study 1 supports the concept that prolotherapy injections produce an inflammatory response. Interestingly, this inflammatory response was not different than saline and needle stick controls. Since dextrose injections did not improve laxity and strength in Study 2, the biomechanical clinical benefit of prolotherapy is not supported. An important, clinically relevant outcome, pain, could not be assessed.
590 $a School code: 0262.
650 4 $a Biology, Physiology. $3 1017816
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0541
690 $a 0719
710 2 $a The University of Wisconsin - Madison. $3 626640
773 0 $t Dissertation Abstracts International $g 67-06B.
790 $a 0262
790 1 0 $a Vanderby, Ray, Jr., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222876