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A functional genomic characterizatio...

Lighthouse, Daniel V.

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A functional genomic characterization of the Drosophila fusome.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	A functional genomic characterization of the Drosophila fusome./
作者:	Lighthouse, Daniel V.
面頁冊數:	153 p.
附註:	Adviser: Allan C. Spradling.
Contained By:	Dissertation Abstracts International69-04B.
標題:	Biology, Cell. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3309705
ISBN:	9780549582885

A functional genomic characterization of the Drosophila fusome.
Lighthouse, Daniel V.

A functional genomic characterization of the Drosophila fusome. - 153 p.

Adviser: Allan C. Spradling.

Thesis (Ph.D.)--The Johns Hopkins University, 2008.

The fusome plays an essential role in prefollicular germ cell development within insects such as Drosophila melanogaster. Understanding the protein composition of the fusome is crucial for gaining insight into its function. By screening a library of Drosophila protein trap strains, we have identified 14 novel fusome-enriched proteins, including many associated with the poorly understood tubulovesicular component of the fusome. Our study of the expression patterns of these lines reveal that the fusome's composition changes during development, that it contains recycling endosomal and lysosomal compartments, and that its composition differs markedly between male and female germ cells. Genetic disruption of the novel fusome components tropomodulin, ferritin-1 heavy chain, and scribble, does not alter fusome structure or female fertility. Thus, a significant number of cellular components enriched within the fusome are not required for normal fusome structure or fertility. In contrast, the fusome-localized recycling endosome marker Rab11 is required for cyst formation, spectrosome vesicle organization, and germline stem cell maintenance, suggesting novel roles for the fusome in intracellular membrane dynamics and cell signaling.

ISBN: 9780549582885Subjects--Topical Terms:

1017686
Biology, Cell.

A functional genomic characterization of the Drosophila fusome.
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