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Analysis of auditory middle latency ...

Millan, Jorge.

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Analysis of auditory middle latency responses at low and high stimulus rates during sleep.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Analysis of auditory middle latency responses at low and high stimulus rates during sleep./
Author:	Millan, Jorge.
Description:	181 p.
Notes:	Adviser: Ozcan Ozdamar.
Contained By:	Dissertation Abstracts International67-11B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3243139
ISBN:	9780542986895

Analysis of auditory middle latency responses at low and high stimulus rates during sleep.
Millan, Jorge.

Analysis of auditory middle latency responses at low and high stimulus rates during sleep. - 181 p.

Adviser: Ozcan Ozdamar.

Thesis (Ph.D.)--University of Miami, 2006.

Auditory evoked responses (AEPs) during sleep indicate the degree of activation and responsiveness of auditory information processing centers during various wakefulness levels. Although AEPs obtained at conventional slow rates during sleep have been described, detailed studies with continuous recordings are still missing. High rate recordings especially at 40 Hz are also suspected to provide more information on brain response generators and their generation mechanisms and processing during sleep. This work introduces new methods to generate, acquire, process and analyze auditory middle latency responses at high stimulation rates during sleep. Overlapped Auditory Evoked Potential (AEP) transient signals are deconvolved using the Continuous Loop Averaging Deconvolution (CLAD) method via frequency domain deconvolution of overlapped responses. The high stimulation rate is obtained using a stimulation sequence specially designed to reduce noise gain in the deconvolution process. Simultaneous acquisition of Auditory Brainstem Response (ABR) and Middle Latency Response (MLR) is obtained at an average stimulation rate of 5 and 40 Hz, using 10 and 100 second EEG recordings. Continuous AEPs were obtained during a short time afternoon sleep session that included awake, stages I-IV and REM sleep stages. To reduce MLR component variability and improve the peak component measurement, a new AEP filtering method was developed. The filtering method implements an optimized zero phase shift spectral high pass filtering combined with time-frequency block wavelet denoising. ABR and MLR peak components were detected and measured automatically using wavelet detail decompositions of the filtered evoked responses. AEP waveform analysis and comparisons between stimulation at 5 Hz and 40 Hz demonstrate no changes in ABR waves but clear and consistent differences in Na, Pa, Nb and Pb components, indicating different auditory response mechanisms. Deconvolved responses at 40 Hz also confirm previous observations on the reduction and disappearance of the Pb component during stage III and IV, obtained with standard averaging methods and stimulation schemes. Reductions on Pb amplitude during sleep showed a strong relation with the corresponding sleep stage. The developed method helps correlating the sleep EEG, indicative of different arousal and consciousness levels, with corresponding responses to auditory stimulation. Waveform differences in middle latency evoked responses at low and high rates need to be further explored.

ISBN: 9780542986895Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Analysis of auditory middle latency responses at low and high stimulus rates during sleep.
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020 $a 9780542986895
035 $a (UMI)AAI3243139
035 $a AAI3243139
040 $a UMI $c UMI
100 1 $a Millan, Jorge. $3 1266027
245 1 0 $a Analysis of auditory middle latency responses at low and high stimulus rates during sleep.
300 $a 181 p.
500 $a Adviser: Ozcan Ozdamar.
500 $a Source: Dissertation Abstracts International, Volume: 67-11, Section: B, page: 6555.
502 $a Thesis (Ph.D.)--University of Miami, 2006.
520 $a Auditory evoked responses (AEPs) during sleep indicate the degree of activation and responsiveness of auditory information processing centers during various wakefulness levels. Although AEPs obtained at conventional slow rates during sleep have been described, detailed studies with continuous recordings are still missing. High rate recordings especially at 40 Hz are also suspected to provide more information on brain response generators and their generation mechanisms and processing during sleep. This work introduces new methods to generate, acquire, process and analyze auditory middle latency responses at high stimulation rates during sleep. Overlapped Auditory Evoked Potential (AEP) transient signals are deconvolved using the Continuous Loop Averaging Deconvolution (CLAD) method via frequency domain deconvolution of overlapped responses. The high stimulation rate is obtained using a stimulation sequence specially designed to reduce noise gain in the deconvolution process. Simultaneous acquisition of Auditory Brainstem Response (ABR) and Middle Latency Response (MLR) is obtained at an average stimulation rate of 5 and 40 Hz, using 10 and 100 second EEG recordings. Continuous AEPs were obtained during a short time afternoon sleep session that included awake, stages I-IV and REM sleep stages. To reduce MLR component variability and improve the peak component measurement, a new AEP filtering method was developed. The filtering method implements an optimized zero phase shift spectral high pass filtering combined with time-frequency block wavelet denoising. ABR and MLR peak components were detected and measured automatically using wavelet detail decompositions of the filtered evoked responses. AEP waveform analysis and comparisons between stimulation at 5 Hz and 40 Hz demonstrate no changes in ABR waves but clear and consistent differences in Na, Pa, Nb and Pb components, indicating different auditory response mechanisms. Deconvolved responses at 40 Hz also confirm previous observations on the reduction and disappearance of the Pb component during stage III and IV, obtained with standard averaging methods and stimulation schemes. Reductions on Pb amplitude during sleep showed a strong relation with the corresponding sleep stage. The developed method helps correlating the sleep EEG, indicative of different arousal and consciousness levels, with corresponding responses to auditory stimulation. Waveform differences in middle latency evoked responses at low and high rates need to be further explored.
590 $a School code: 0125.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Audiology. $3 1018138
650 4 $a Psychology, Cognitive. $3 1017810
690 $a 0300
690 $a 0541
690 $a 0633
710 2 $a University of Miami. $3 1017483
773 0 $t Dissertation Abstracts International $g 67-11B.
790 $a 0125
790 1 0 $a Ozdamar, Ozcan, $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3243139