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Vitamin E (tocotrienols) and prostat...

Muenyi, Christian Mbangha.

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Vitamin E (tocotrienols) and prostate cancer: A proteomics approach.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Vitamin E (tocotrienols) and prostate cancer: A proteomics approach./
Author:	Muenyi, Christian Mbangha.
Description:	72 p.
Notes:	Adviser: William L. Stone.
Contained By:	Masters Abstracts International46-01.
Subject:	Chemistry, Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1445290
ISBN:	9780549109082

Vitamin E (tocotrienols) and prostate cancer: A proteomics approach.
Muenyi, Christian Mbangha.

Vitamin E (tocotrienols) and prostate cancer: A proteomics approach. - 72 p.

Adviser: William L. Stone.

Thesis (M.S.)--East Tennessee State University, 2007.

Proteomics is the large scale study of proteins in cells or organisms. The purpose of this study was to characterize the proteomic alterations occurring in a prostate cancer (LNCaP) cell line after treatment with delta-tocotrienol (a form of vitamin E not very prevalent from most dietary sources). We found that both gamma- and delta-tocotrienols induced time and concentration dependent growth inhibition and programmed cell dead (apoptosis) in LNCaP cells. Secondly, we used two-dimensional gel electrophoresis (2-DE) to characterize changes in protein expression levels associated with this treatment. Our results show that a specific set of proteins are regulated at both early and late times following treatment with delta-tocotrienol and these proteins have been characterized by their apparent molecular weights and isoelectric points. The alteration observed at early time points are particularly interesting because these changes are likely to reflect the underlying molecular mechanisms for triggering cancer cell death.

ISBN: 9780549109082Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Vitamin E (tocotrienols) and prostate cancer: A proteomics approach.
LDR:01884nam 2200277 a 45 001 941640
005 20110519
008 110519s2007 eng d
020 $a 9780549109082
035 $a (UMI)AAI1445290
035 $a AAI1445290
040 $a UMI $c UMI
100 1 $a Muenyi, Christian Mbangha. $3 1265738
245 1 0 $a Vitamin E (tocotrienols) and prostate cancer: A proteomics approach.
300 $a 72 p.
500 $a Adviser: William L. Stone.
500 $a Source: Masters Abstracts International, Volume: 46-01, page: .
502 $a Thesis (M.S.)--East Tennessee State University, 2007.
520 $a Proteomics is the large scale study of proteins in cells or organisms. The purpose of this study was to characterize the proteomic alterations occurring in a prostate cancer (LNCaP) cell line after treatment with delta-tocotrienol (a form of vitamin E not very prevalent from most dietary sources). We found that both gamma- and delta-tocotrienols induced time and concentration dependent growth inhibition and programmed cell dead (apoptosis) in LNCaP cells. Secondly, we used two-dimensional gel electrophoresis (2-DE) to characterize changes in protein expression levels associated with this treatment. Our results show that a specific set of proteins are regulated at both early and late times following treatment with delta-tocotrienol and these proteins have been characterized by their apparent molecular weights and isoelectric points. The alteration observed at early time points are particularly interesting because these changes are likely to reflect the underlying molecular mechanisms for triggering cancer cell death.
590 $a School code: 0069.
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0487
690 $a 0570
710 2 0 $a East Tennessee State University. $3 1017802
773 0 $t Masters Abstracts International $g 46-01.
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790 1 0 $a Stone, William L., $e advisor
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792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1445290