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Biochemical and metabolic causes of ...

Ko, Kwang Suk.

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Biochemical and metabolic causes of taurine deficiency in large dogs.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Biochemical and metabolic causes of taurine deficiency in large dogs./
作者:	Ko, Kwang Suk.
面頁冊數:	130 p.
附註:	Adviser: Quinton R. Rogers.
Contained By:	Dissertation Abstracts International67-09B.
標題:	Biology, Veterinary Science. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3236020
ISBN:	9780542898938

Biochemical and metabolic causes of taurine deficiency in large dogs.
Ko, Kwang Suk.

Biochemical and metabolic causes of taurine deficiency in large dogs. - 130 p.

Adviser: Quinton R. Rogers.

Thesis (Ph.D.)--University of California, Davis, 2006.

Even though dogs are known to synthesize sufficient taurine to meet their biological needs from its precursors, sulfur amino acids (SAA), taurine deficiency and dilated cardiomyopathy (DCM) in canines have been reported mainly in large breed-dogs. Since lamb and rice diets without copper (Cu) supplementation have been implicated as possible causes of taurine deficiency in dogs, Cu deficiency, dietary rice bran (RB) and capacity to synthesize taurine were studied in small dogs (SD) and large dogs (LD). Cu deficiency was induced in rats, as a model for dogs, and their taurine status and hepatic activities of two enzymes involved in synthesizing taurine, cysteine dioxygenase (CDO) and cysteine sulfinic acid decarboxylase (CSAD), were determined. Cu deficient rats did not decrease the concentrations of taurine in plasma (PL), whole blood (WB) or urine or the activity of CDO, as compared to that of rats fed adequate Cu. Hepatic CSAD in Cu deficient rats was significantly higher than that of normal rats, as commonly occurs with lower intakes of protein. The capacities to synthesize taurine were compared between SD and LD under two different dietary conditions. First, SD and LD were fed the amount of diet for each dog to maintain ideal body condition and then the SD and LD were paired and fed the same amount of diet per metabolic body weight. In both studies, LD showed a significantly lower capacity to synthesize taurine: Finally, the effects of dietary RB was compared to that of other fibers, cellulose (CL) and beet pulp (BP), on taurine status and fecal bile acid excretion in large dogs. The dogs were fed purified diets containing the different fiber sources for 12 weeks and their taurine status and fecal bile acids were measured. The BP-containing diets lowered PL and WB taurine concentrations and caused the highest fecal bile acid excretions, compared to dogs fed diets containing CL or RB. These results support the hypothesis that taurine status in LD relative to SD is lower because LD ingest less energy, and thus less SAA/kg BW 0.75 than SD.

ISBN: 9780542898938Subjects--Topical Terms:

1021733
Biology, Veterinary Science.

Biochemical and metabolic causes of taurine deficiency in large dogs.
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502 $a Thesis (Ph.D.)--University of California, Davis, 2006.
520 $a Even though dogs are known to synthesize sufficient taurine to meet their biological needs from its precursors, sulfur amino acids (SAA), taurine deficiency and dilated cardiomyopathy (DCM) in canines have been reported mainly in large breed-dogs. Since lamb and rice diets without copper (Cu) supplementation have been implicated as possible causes of taurine deficiency in dogs, Cu deficiency, dietary rice bran (RB) and capacity to synthesize taurine were studied in small dogs (SD) and large dogs (LD). Cu deficiency was induced in rats, as a model for dogs, and their taurine status and hepatic activities of two enzymes involved in synthesizing taurine, cysteine dioxygenase (CDO) and cysteine sulfinic acid decarboxylase (CSAD), were determined. Cu deficient rats did not decrease the concentrations of taurine in plasma (PL), whole blood (WB) or urine or the activity of CDO, as compared to that of rats fed adequate Cu. Hepatic CSAD in Cu deficient rats was significantly higher than that of normal rats, as commonly occurs with lower intakes of protein. The capacities to synthesize taurine were compared between SD and LD under two different dietary conditions. First, SD and LD were fed the amount of diet for each dog to maintain ideal body condition and then the SD and LD were paired and fed the same amount of diet per metabolic body weight. In both studies, LD showed a significantly lower capacity to synthesize taurine: Finally, the effects of dietary RB was compared to that of other fibers, cellulose (CL) and beet pulp (BP), on taurine status and fecal bile acid excretion in large dogs. The dogs were fed purified diets containing the different fiber sources for 12 weeks and their taurine status and fecal bile acids were measured. The BP-containing diets lowered PL and WB taurine concentrations and caused the highest fecal bile acid excretions, compared to dogs fed diets containing CL or RB. These results support the hypothesis that taurine status in LD relative to SD is lower because LD ingest less energy, and thus less SAA/kg BW 0.75 than SD.
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