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Chondroplastic conversion and calcif...

Bennett, Brian J.

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Chondroplastic conversion and calcification of advanced atherosclerotic lesions: The impact of bone regulatory proteins and diet.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Chondroplastic conversion and calcification of advanced atherosclerotic lesions: The impact of bone regulatory proteins and diet./
Author:	Bennett, Brian J.
Description:	150 p.
Notes:	Adviser: Michael E. Rosenfeld.
Contained By:	Dissertation Abstracts International67-02B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3205833
ISBN:	9780542543739

Chondroplastic conversion and calcification of advanced atherosclerotic lesions: The impact of bone regulatory proteins and diet.
Bennett, Brian J.

Chondroplastic conversion and calcification of advanced atherosclerotic lesions: The impact of bone regulatory proteins and diet. - 150 p.

Adviser: Michael E. Rosenfeld.

Thesis (Ph.D.)--University of Washington, 2006.

Conclusions. These results indicate that the ApoE-/- mouse is a viable model for studying atherosclerosis associated vascular calcification. Both diet and genetic approaches are able to alter vascular calcification in this model.

ISBN: 9780542543739Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Chondroplastic conversion and calcification of advanced atherosclerotic lesions: The impact of bone regulatory proteins and diet.
LDR:03489nam 2200325 a 45 001 941505
005 20110519
008 110519s2006 eng d
020 $a 9780542543739
035 $a (UMI)AAI3205833
035 $a AAI3205833
040 $a UMI $c UMI
100 1 $a Bennett, Brian J. $3 1265595
245 1 0 $a Chondroplastic conversion and calcification of advanced atherosclerotic lesions: The impact of bone regulatory proteins and diet.
300 $a 150 p.
500 $a Adviser: Michael E. Rosenfeld.
500 $a Source: Dissertation Abstracts International, Volume: 67-02, Section: B, page: 0813.
502 $a Thesis (Ph.D.)--University of Washington, 2006.
520 $a Conclusions. These results indicate that the ApoE-/- mouse is a viable model for studying atherosclerosis associated vascular calcification. Both diet and genetic approaches are able to alter vascular calcification in this model.
520 $a Objective. The development of advanced atherosclerotic lesions is a common pathology underlying most cardiovascular deaths. Calcification of advanced atherosclerotic lesions in humans and mice is common but the time course, cell types and mechanism(s) associated with calcification are not well understood. The ApoE-/- mouse is commonly used in atherosclerosis research and may be a promising model to study atherosclerosis associated vascular calcification. I along with several collaborators characterized the calcification of advanced atherosclerotic lesions in ApoE-/- mice. This model then was used to investigate the effect of several potential mediators of vascular calcification. The effect of the isoflavone genistein on vascular calcification was assessed using a classic feeding study approach. Using intercrosses of genetically engineered mice, the role of several bone regulatory proteins, osteoprotegerin, osteopontin and matrix-gla protein, was assessed.
520 $a Results. Calcification of advanced atherosclerotic lesions in ApoE-/- mice is preceded by the formation of fibro-fatty nodules that are populated by cells that morphologically resemble chondrocytes. These cells are temporally and spatially associated deposits of hydroxyapatite and express the same proteins as chondrocytes within developing bone.
520 $a A diet enriched with genistein reduces aortic calcium content and elevated circulating OPG. Generation of OPG-/-.apoE-/- mice indicates that OPG has a role in modulating plaque size and calcification. Because OPG-/-.ApoE-/- mice had increased lesion area and aortic calcium content. Analysis of lesion morphology indicates that OPG may act as a survival factor within the lesion.
520 $a Studies of mgp indicated that mgp inactivation increases lesion size and results in a dramatic change in lesion composition. Mgp-/-.ApoE-/- have increased chondroplastic conversion and plaque calcification at 18 weeks of age when ApoE-/- controls have less complicated and smaller fatty streaks forming. Unfortunately, there was no effect of OPN on atherosclerosis or calcification of the atherosclerotic plaques. However, there was an indication that OPN may modulate the chondroplastic conversion and calcification of the media underlying the lesion.
590 $a School code: 0250.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0433
690 $a 0570
710 2 0 $a University of Washington. $3 545923
773 0 $t Dissertation Abstracts International $g 67-02B.
790 $a 0250
790 1 0 $a Rosenfeld, Michael E., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3205833