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Hydrogen-bonded films and capsules a...

Kozlovskaya, Veronika.

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Hydrogen-bonded films and capsules as platforms for stimuli-responsive materials.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Hydrogen-bonded films and capsules as platforms for stimuli-responsive materials./
Author:	Kozlovskaya, Veronika.
Description:	207 p.
Notes:	Adviser: Svetlana Sukhishvili.
Contained By:	Dissertation Abstracts International69-06B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3317882
ISBN:	9780549665069

Hydrogen-bonded films and capsules as platforms for stimuli-responsive materials.
Kozlovskaya, Veronika.

Hydrogen-bonded films and capsules as platforms for stimuli-responsive materials. - 207 p.

Adviser: Svetlana Sukhishvili.

Thesis (Ph.D.)--Stevens Institute of Technology, 2008.

We found that permeability of such hydrogel capsules to species with a certain molecular weight also strongly depend on environmental pH- and salt conditions and can be switched on/off allowing the so-called molecular sieving.

ISBN: 9780549665069Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Hydrogen-bonded films and capsules as platforms for stimuli-responsive materials.
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020 $a 9780549665069
035 $a (UMI)AAI3317882
035 $a AAI3317882
040 $a UMI $c UMI
100 1 $a Kozlovskaya, Veronika. $3 1265042
245 1 0 $a Hydrogen-bonded films and capsules as platforms for stimuli-responsive materials.
300 $a 207 p.
500 $a Adviser: Svetlana Sukhishvili.
500 $a Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: .
502 $a Thesis (Ph.D.)--Stevens Institute of Technology, 2008.
520 $a We found that permeability of such hydrogel capsules to species with a certain molecular weight also strongly depend on environmental pH- and salt conditions and can be switched on/off allowing the so-called molecular sieving.
520 $a Needs in controlled delivery of drugs, fragrances, cosmetics, biomedical engineering and catalysis urge a design and development of stimuli-responsive polymeric containers. This thesis introduces new routes for designing stimuli-responsive polymeric carriers with well-controlled properties of the capsule wall. Using layer-by-layer deposition technique, we produced novel pH-sensitive multilayer capsules by hydrogen-bonding self-assembly of poly (carboxylic acid)s and uncharged water soluble polymers onto particulate substrates followed by dissolution of the multilayer coated particles.
520 $a To stabilize hydrogen-bonded multilayer capsules in a wide pH range, we explored chemical crosslinking via carbodiimide chemistry and obtained crosslinked hydrogel capsules made of either poly(carboxylic acid)s or polyacid/neutral polymers (one- and two-component systems, respectively). The one-component hydrogel capsules of a variety of weak poly(carboxylic acid)s, such as poly(acrylic acid), poly(methacrylic acid), or poly(ethacrylic acid), or two-component capsules of poly(carboxylic acid)/poly(N-vynylpyrrolidone-co-NH2) or poly(N-vinylcaprolactam-co-NH2) copolymers have ultrathin capsule walls of controlled thickness and show reversible swelling/deswelling in response to pH and ionic strength. Reversible softening of the hydrogel capsules is observed in response to pH variations. The hydrogel capsule pH response can be adjusted in a wide range of pH from slightly acidic to basic via: (a) changing hydrophobicity of self-assembled polymers or (b) binding a polycation to the capsule wall. Our studies show that the pH value at which capsule swelling occurred is largely determined by pK a of a poly(carboxylic acid) and only slightly by hydrophobicity of neutral polymers. Swelling pH of the polyacid capsules can be further tuned through binding various polycations to the hydrogel capsule walls. The capability of tuning their pH response to the desired range is crucial for their future applications as responsive materials for controlled delivery of chemicals.
520 $a We designed three different types of capsule pH-swelling profiles that can be tuned to a desirable pH range. We demonstrate that the novel capsules with tunable swelling/deswelling pH can be used for pH- and salt-induced encapsulation and release of functional molecules.
590 $a School code: 0733.
650 4 $a Chemistry, Polymer. $3 1018428
690 $a 0495
710 2 $a Stevens Institute of Technology. $3 1019501
773 0 $t Dissertation Abstracts International $g 69-06B.
790 $a 0733
790 1 0 $a Sukhishvili, Svetlana, $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3317882