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Sunscreen skin distribution influenc...

Yang, Jing.

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Sunscreen skin distribution influences in vivo photoprotective effects.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Sunscreen skin distribution influences in vivo photoprotective effects./
Author:	Yang, Jing.
Description:	159 p.
Notes:	Adviser: Linda A. Felton.
Contained By:	Dissertation Abstracts International68-07B.
Subject:	Health Sciences, Toxicology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3273447
ISBN:	9780549135814

Sunscreen skin distribution influences in vivo photoprotective effects.
Yang, Jing.

Sunscreen skin distribution influences in vivo photoprotective effects. - 159 p.

Adviser: Linda A. Felton.

Thesis (Ph.D.)--The University of New Mexico, 2007.

Skin cancer is the most common type of cancer reported in the United States today and the use of sunscreen has been advocated as the best prevention against this type of cancer. Our research has focused on using an auxiliary compound, hydroxypropyl-beta-cyclodextrin (HPCD), to form inclusion complexes with ultraviolet (UV) absorbers and to optimize the physicochemical properties of the sunscreen products. The objective of this study was to determine the influence of HPCD on the skin distribution of a model UV absorber, 2-hydroxy-4-methoxybenzophenone (oxybenzone), and to compare the corresponding photoprotective effects. The sunscreen formulations containing 2.67mg/ml of oxybenzone and up to 20% (w/w) HPCD were prepared and applied to SKH-1 hairless mouse skin mounted on Franz diffusion cells for 0.5 to 4 hours. The quantities of oxybenzone on the skin surface and distributed in the stratum corneum (SC), viable epidermis and dermis, as well as the receptor fluid were quantified. The majority of the applied oxybenzone from the 0 and 20% HPCD formulations were retained on the skin surface. The 10% HPCD formulation greatly increased skin penetration of oxybenzone and a preferential accumulation in the SC was observed. In vivo, HPCD complexation did not prevent oxybenzone from reacting with UV light. Acute UV-induced epidermal lipid disruption and skin edema were reduced to the greatest extent with the formulation exhibiting a high deposition of the UV absorber in the SC. These findings suggest that locating the UV-absorbing agent to the SC can effectively prevent the interaction between UV light and macromolecules such as the intercellular lipids, thus reduce free radical generation and free radical-related skin damage. In the chronic study, skin tumor incidence was significantly suppressed when the UV absorber was targeted to the SC. This work indicates that HPCD complexation technology is a promising strategy to improve sunscreen products.

ISBN: 9780549135814Subjects--Topical Terms:

1017752
Health Sciences, Toxicology.

Sunscreen skin distribution influences in vivo photoprotective effects.
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020 $a 9780549135814
035 $a (UMI)AAI3273447
035 $a AAI3273447
040 $a UMI $c UMI
100 1 $a Yang, Jing. $3 1031179
245 1 0 $a Sunscreen skin distribution influences in vivo photoprotective effects.
300 $a 159 p.
500 $a Adviser: Linda A. Felton.
500 $a Source: Dissertation Abstracts International, Volume: 68-07, Section: B, page: 4433.
502 $a Thesis (Ph.D.)--The University of New Mexico, 2007.
520 $a Skin cancer is the most common type of cancer reported in the United States today and the use of sunscreen has been advocated as the best prevention against this type of cancer. Our research has focused on using an auxiliary compound, hydroxypropyl-beta-cyclodextrin (HPCD), to form inclusion complexes with ultraviolet (UV) absorbers and to optimize the physicochemical properties of the sunscreen products. The objective of this study was to determine the influence of HPCD on the skin distribution of a model UV absorber, 2-hydroxy-4-methoxybenzophenone (oxybenzone), and to compare the corresponding photoprotective effects. The sunscreen formulations containing 2.67mg/ml of oxybenzone and up to 20% (w/w) HPCD were prepared and applied to SKH-1 hairless mouse skin mounted on Franz diffusion cells for 0.5 to 4 hours. The quantities of oxybenzone on the skin surface and distributed in the stratum corneum (SC), viable epidermis and dermis, as well as the receptor fluid were quantified. The majority of the applied oxybenzone from the 0 and 20% HPCD formulations were retained on the skin surface. The 10% HPCD formulation greatly increased skin penetration of oxybenzone and a preferential accumulation in the SC was observed. In vivo, HPCD complexation did not prevent oxybenzone from reacting with UV light. Acute UV-induced epidermal lipid disruption and skin edema were reduced to the greatest extent with the formulation exhibiting a high deposition of the UV absorber in the SC. These findings suggest that locating the UV-absorbing agent to the SC can effectively prevent the interaction between UV light and macromolecules such as the intercellular lipids, thus reduce free radical generation and free radical-related skin damage. In the chronic study, skin tumor incidence was significantly suppressed when the UV absorber was targeted to the SC. This work indicates that HPCD complexation technology is a promising strategy to improve sunscreen products.
590 $a School code: 0142.
650 4 $a Health Sciences, Toxicology. $3 1017752
690 $a 0383
710 2 $a The University of New Mexico. $3 1018024
773 0 $t Dissertation Abstracts International $g 68-07B.
790 $a 0142
790 1 0 $a Felton, Linda A., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3273447