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Biomarkers of endothelial function a...

Rejman, Karol Pohlman.

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Biomarkers of endothelial function and early renal impairment: Associations with type 2 diabetes mellitus (Results from the Western New York Study).

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Biomarkers of endothelial function and early renal impairment: Associations with type 2 diabetes mellitus (Results from the Western New York Study)./
Author:	Rejman, Karol Pohlman.
Description:	114 p.
Notes:	Adviser: Richard P. Donahue.
Contained By:	Dissertation Abstracts International67-11B.
Subject:	Health Sciences, Epidemiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3244276
ISBN:	9780542999734

Biomarkers of endothelial function and early renal impairment: Associations with type 2 diabetes mellitus (Results from the Western New York Study).
Rejman, Karol Pohlman.

Biomarkers of endothelial function and early renal impairment: Associations with type 2 diabetes mellitus (Results from the Western New York Study). - 114 p.

Adviser: Richard P. Donahue.

Thesis (Ph.D.)--State University of New York at Buffalo, 2007.

Conclusions. E-selectin is an independent predictor of incident type 2 diabetes in this community-dwelling, middle aged population. Cystatin-c does not predict incident type 2 diabetes in this population.

ISBN: 9780542999734Subjects--Topical Terms:

1019544
Health Sciences, Epidemiology.

Biomarkers of endothelial function and early renal impairment: Associations with type 2 diabetes mellitus (Results from the Western New York Study).
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020 $a 9780542999734
035 $a (UMI)AAI3244276
035 $a AAI3244276
040 $a UMI $c UMI
100 1 $a Rejman, Karol Pohlman. $3 1264978
245 1 0 $a Biomarkers of endothelial function and early renal impairment: Associations with type 2 diabetes mellitus (Results from the Western New York Study).
300 $a 114 p.
500 $a Adviser: Richard P. Donahue.
500 $a Source: Dissertation Abstracts International, Volume: 67-11, Section: B, page: 6286.
502 $a Thesis (Ph.D.)--State University of New York at Buffalo, 2007.
520 $a Conclusions. E-selectin is an independent predictor of incident type 2 diabetes in this community-dwelling, middle aged population. Cystatin-c does not predict incident type 2 diabetes in this population.
520 $a Few studies have been done to identify biomarkers that predict incident type 2 diabetes.
520 $a Hypotheses. Increased levels of E-selectin and cystatin-C will predict incident type 2 diabetes mellitus.
520 $a Type 2 diabetes mellitus is a significant public health problem in the United States. According to the National Center for Chronic Disease Prevention and Health Promotion, over 19 million Americans (7% of the population) have diabetes and 16 million people have prediabetic conditions.
520 $a Methods. The WNY Follow-up Study is a six year follow-up study of a population-based sample from the Western New York Health Study (WNYHS). WNYHS participants were a random sample initially recruited from Erie and Niagara counties (mean age 54 years, 95% white) without evident CVD and examined from 1996-2000.
520 $a At the first follow-up examination in 2003-2004, incident cases of DM were defined by self-report plus the use of oral hypoglycemic agents or insulin, or fasting plasma glucose greater than 125 mg/dl. The cases were matched to controls (3:1) on the basis of gender, ethnicity, baseline glycemic status (<110 mg/dl, 110-125 mg/dl), and year of entry into the study.
520 $a Conditional logistic regression was used to estimate the odds ratio (OR)and 95% confidence intervals (95%CI) of type 2 diabetes mellitus. The OR (95% CI) of E-selectin for diabetes conditioned on only the matching variables was 2.63 (95% CI: 1.06, 6.54; p=0.04) (comparing the top tertile of E-selectin to the bottom). Control for additional covariates included age, BMI, cigarette use, physical activity, family history of diabetes, and alcohol use. The unadjusted OR of cystatin C for type 2 diabetes was 1.20 (95%CI: 0.61-2.67; p=0.60) for the top quintile versus the remainder.
590 $a School code: 0656.
650 4 $a Health Sciences, Epidemiology. $3 1019544
690 $a 0766
710 2 $a State University of New York at Buffalo. $3 1017814
773 0 $t Dissertation Abstracts International $g 67-11B.
790 $a 0656
790 1 0 $a Donahue, Richard P., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3244276