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Characterization of the effect of ca...

Park, Sang-Kyu.

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Characterization of the effect of caloric restriction and antioxidant supplementation on age-related transcriptional alterations in the mouse heart and brain.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Characterization of the effect of caloric restriction and antioxidant supplementation on age-related transcriptional alterations in the mouse heart and brain./
作者:	Park, Sang-Kyu.
面頁冊數:	182 p.
附註:	Adviser: Tomas A. Prolla.
Contained By:	Dissertation Abstracts International67-09B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3234878
ISBN:	9780542888571

Characterization of the effect of caloric restriction and antioxidant supplementation on age-related transcriptional alterations in the mouse heart and brain.
Park, Sang-Kyu.

Characterization of the effect of caloric restriction and antioxidant supplementation on age-related transcriptional alterations in the mouse heart and brain. - 182 p.

Adviser: Tomas A. Prolla.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2006.

To investigate the global effects of vitamin E supplementation on aging, we used DNA microarrays to measure transcriptional alterations in the heart and neocortex of 30-month-old B6C3F1 mice supplemented with alpha- and gamma-tocopherol since middle age (15 months). Gene expression profiles were obtained from 5-month-old controls, 30-month-old controls and 30-month-old mice supplemented with alpha-tocopherol (1g/kg), or a mixture of alpha- and gamma-tocopherol (500mg/kg of each tocopherol). In the heart, both tocopherol supplementations were effective in inhibiting the expression of genes associated with cardiomyocyte hypertrophy and increased innate immunity, while having a moderate effect on age-related transcriptional alterations linked to the stress response and protein synthesis. In the neocortex, age-related induction of genes encoding ribosomal proteins and proteins involved in ATP biosynthesis was markedly prevented by the mixture of alpha- and gamma-tocopherol, but not by alpha-tocopherol alone. These results demonstrate that middle age-onset dietary supplementation with alpha- and gamma-tocopherol can partially prevent transcriptional profiles associated with aging, and that these effects are tissue and tocopherol-specific.

ISBN: 9780542888571Subjects--Topical Terms:

1017730
Biology, Genetics.

Characterization of the effect of caloric restriction and antioxidant supplementation on age-related transcriptional alterations in the mouse heart and brain.
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245 1 0 $a Characterization of the effect of caloric restriction and antioxidant supplementation on age-related transcriptional alterations in the mouse heart and brain.
300 $a 182 p.
500 $a Adviser: Tomas A. Prolla.
500 $a Source: Dissertation Abstracts International, Volume: 67-09, Section: B, page: 4842.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2006.
520 $a To investigate the global effects of vitamin E supplementation on aging, we used DNA microarrays to measure transcriptional alterations in the heart and neocortex of 30-month-old B6C3F1 mice supplemented with alpha- and gamma-tocopherol since middle age (15 months). Gene expression profiles were obtained from 5-month-old controls, 30-month-old controls and 30-month-old mice supplemented with alpha-tocopherol (1g/kg), or a mixture of alpha- and gamma-tocopherol (500mg/kg of each tocopherol). In the heart, both tocopherol supplementations were effective in inhibiting the expression of genes associated with cardiomyocyte hypertrophy and increased innate immunity, while having a moderate effect on age-related transcriptional alterations linked to the stress response and protein synthesis. In the neocortex, age-related induction of genes encoding ribosomal proteins and proteins involved in ATP biosynthesis was markedly prevented by the mixture of alpha- and gamma-tocopherol, but not by alpha-tocopherol alone. These results demonstrate that middle age-onset dietary supplementation with alpha- and gamma-tocopherol can partially prevent transcriptional profiles associated with aging, and that these effects are tissue and tocopherol-specific.
520 $a We also identified a panel of biomarkers of aging that are differentially expressed in several strains of young and old mice (129sv, BALB/c, CBA, DBA, B6, C3H, and B6C3F1) through DNA microarrays and tested the effect of caloric restriction and dietary supplementation of several antioxidants on the expression of identified biomarkers of aging. In heart, age-related changes of six genes are common in all strains tested: complement component 4, chemokine ligand 14, component of Sp100-rs, phenylalanine hydroxylase, src family associated phosphoprotein 2, and p16. In the cerebellum, identified biomarkers of aging include complement component 1q (alpha polypeptide), complement component 4, P lysozyme structural, glial fbrillary acidic protein, cathepsin s, and p16. Caloric restriction showed significant effect on age-related transcriptional changes of biomarkers of aging. Among antioxidants, lycopene, resveratrol, acetyl-L-carnitine, and tempol were as effective as calorie restriction in heart and alpha-lipoic acid and coenzyme Q10 were as effective as caloric restriction in cerebellum. This study provides tissue-specific biomarkers of aging in mice that can be used to measure the aging process, and suggests that antioxidant supplementation can partially attenuate the age-related changes in expression in mice.
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