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A novel role for annulate lamellae i...

Boulware, Michael Joseph.

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A novel role for annulate lamellae in calcium ion signaling .

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	A novel role for annulate lamellae in calcium ion signaling ./
作者:	Boulware, Michael Joseph.
面頁冊數:	100 p.
附註:	Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5157.
Contained By:	Dissertation Abstracts International68-08B.
標題:	Biology, Cell. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3280708
ISBN:	9780549218319

A novel role for annulate lamellae in calcium ion signaling .
Boulware, Michael Joseph.

A novel role for annulate lamellae in calcium ion signaling . - 100 p.

Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5157.

Thesis (Ph.D.)--University of Minnesota, 2007.

Fertilization competency results from hormone-induced remodeling of oocytes into eggs. The signaling pathways that effect this change exemplify bistability, where brief hormone exposure irrevocably switches cell fate. In Xenopus, changes in Ca2+ signaling epitomize such remodeling: the reversible Ca2+ signaling phenotype of oocytes rapidly adapts to support irreversible propagation of the fertilization Ca 2+ wave. In this thesis, I have optically dissected the functional architecture of the Ca2+ release apparatus underpinning this reorganization by simultaneously resolving IP3 receptor (IP3R) activity with endoplasmic reticulum (ER) structure. I show that changes in Ca2+ signaling correlate with IP 3R redistribution from specialized ER subdomains called annulate lamellae (AL), where Ca2+ release activity is attenuated, into IP 3R-replete patches in the cortical ER of eggs which support the fertilization Ca2+ wave. Mechanistically, I show that IP3R inhibition is relieved during maturation when annulate lamellae pore complexes (ALPCs) dismantle from AL and that regions of the ER denuded of ALPCs show Ca 2+ signaling competency. This ensures integration of signal competent IP3Rs into the morphologically distinct ER patches of the egg cortex.

ISBN: 9780549218319Subjects--Topical Terms:

1017686
Biology, Cell.

A novel role for annulate lamellae in calcium ion signaling .
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245 1 2 $a A novel role for annulate lamellae in calcium ion signaling .
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500 $a Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5157.
502 $a Thesis (Ph.D.)--University of Minnesota, 2007.
520 $a Fertilization competency results from hormone-induced remodeling of oocytes into eggs. The signaling pathways that effect this change exemplify bistability, where brief hormone exposure irrevocably switches cell fate. In Xenopus, changes in Ca2+ signaling epitomize such remodeling: the reversible Ca2+ signaling phenotype of oocytes rapidly adapts to support irreversible propagation of the fertilization Ca 2+ wave. In this thesis, I have optically dissected the functional architecture of the Ca2+ release apparatus underpinning this reorganization by simultaneously resolving IP3 receptor (IP3R) activity with endoplasmic reticulum (ER) structure. I show that changes in Ca2+ signaling correlate with IP 3R redistribution from specialized ER subdomains called annulate lamellae (AL), where Ca2+ release activity is attenuated, into IP 3R-replete patches in the cortical ER of eggs which support the fertilization Ca2+ wave. Mechanistically, I show that IP3R inhibition is relieved during maturation when annulate lamellae pore complexes (ALPCs) dismantle from AL and that regions of the ER denuded of ALPCs show Ca 2+ signaling competency. This ensures integration of signal competent IP3Rs into the morphologically distinct ER patches of the egg cortex.
520 $a My data show: first, that IP3R sensitivity is regulated with high spatial acuity even between contiguous ER regions; second, that drastic reorganization of Ca2+ signaling dynamics can be driven by subcellular redistribution, in the absence of changes in channel number or molecular/familial Ca2+ channel diversity. Finally, these results define a novel role for AL in Ca2+ signaling in the acquisition of fertilization competency.
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