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Mechanisms of blood-brain and blood-...

Chandorkar, Gurudatt Ajay.

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Mechanisms of blood-brain and blood-cerebrospinal fluid transport of aluminum in rats.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Mechanisms of blood-brain and blood-cerebrospinal fluid transport of aluminum in rats./
作者:	Chandorkar, Gurudatt Ajay.
面頁冊數:	193 p.
附註:	Adviser: Srikumaran Melethil.
Contained By:	Dissertation Abstracts International68-04B.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3257305

Mechanisms of blood-brain and blood-cerebrospinal fluid transport of aluminum in rats.
Chandorkar, Gurudatt Ajay.

Mechanisms of blood-brain and blood-cerebrospinal fluid transport of aluminum in rats. - 193 p.

Adviser: Srikumaran Melethil.

Thesis (Ph.D.)--University of Missouri - Kansas City, 2007.

Aluminum (Al) is a neurotoxin implicated in several neurological disorders. However, the mechanisms of its transport across the blood-brain barrier remain unknown. Previous studies have speculated the role of transferrin in the transport of Al across the blood-brain barrier (BBB). However, this hypothesis remains to be confirmed. The effect of the salt-form and dose (0.5, 1.0 and 2.0 mg/kg) on the unidirectional transport rate constants (kin), were investigated to determine the mechanisms of BBB transport of aluminum, using the unanesthetized rat as an in-vivo animal model. In addition, differences in regional permeability to aluminum were investigated in four brain regions (pons and medulla, cerebellum, cortex, and a composite of the remainder of the brain termed 'others').Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Mechanisms of blood-brain and blood-cerebrospinal fluid transport of aluminum in rats.
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100 1 $a Chandorkar, Gurudatt Ajay. $3 1262887
245 1 0 $a Mechanisms of blood-brain and blood-cerebrospinal fluid transport of aluminum in rats.
300 $a 193 p.
500 $a Adviser: Srikumaran Melethil.
500 $a Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2275.
502 $a Thesis (Ph.D.)--University of Missouri - Kansas City, 2007.
520 $a Aluminum (Al) is a neurotoxin implicated in several neurological disorders. However, the mechanisms of its transport across the blood-brain barrier remain unknown. Previous studies have speculated the role of transferrin in the transport of Al across the blood-brain barrier (BBB). However, this hypothesis remains to be confirmed. The effect of the salt-form and dose (0.5, 1.0 and 2.0 mg/kg) on the unidirectional transport rate constants (kin), were investigated to determine the mechanisms of BBB transport of aluminum, using the unanesthetized rat as an in-vivo animal model. In addition, differences in regional permeability to aluminum were investigated in four brain regions (pons and medulla, cerebellum, cortex, and a composite of the remainder of the brain termed 'others').
520 $a Both in-vivo pharmacokinetics and blood-brain barrier transport of aluminum were influenced by the salt-form administered. Blood aluminum concentrations following the administration of the citrate salt (0.5 mg/kg dose) were significantly lower (p < 0.05) than those following the administration of sulfate, chloride and lactate salts. However, brain transport of aluminum following the administration of the citrate salt was significantly higher than the other salts tested. Dose-dependent studies with aluminum citrate showed that in the dose range studied, the transport rate constants for the blood-brain barrier transport of aluminum were independent of the dose administered suggesting that transport of aluminum across the blood-brain barrier may be via passive diffusion. These results compared well with the in-vitro and in-situ studies previously conducted to determine the mechanisms of blood-brain barrier transport of aluminum. No regional differences in brain permeability to aluminum were observed.
520 $a The mechanisms of aluminum transport across the blood-cerebrospinal fluid (CSF) barrier were investigated by determining the transport rate constants for aluminum following an intravenous administration of aluminum citrate (1.0 and 2.0 mg/kg dose). Data analyses were conducted using model-dependent and model-independent methods. The transport rate constants for blood-CSF transport of aluminum were independent of the dose administered indicating that the blood-CSF transport of aluminum in the dose range studied could also be diffusion mediated.
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