東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Micromachining, capillary electropho...

Fan, Zhonghui Hugh.

Linked to FindBook

Google Book

Amazon

博客來

Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors./
Author:	Fan, Zhonghui Hugh.
Description:	234 p.
Notes:	Adviser: Jed Harrison.
Contained By:	Dissertation Abstracts International57-08B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NN11203
ISBN:	0612112039

Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors.
Fan, Zhonghui Hugh.

Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors. - 234 p.

Adviser: Jed Harrison.

Thesis (Ph.D.)--University of Alberta (Canada), 1994.

Chemical sensors have found considerable applications in biotechnology, process control, environmental and medical sciences, as they can be used to make measurements rapidly, repetitively, or even outside the lab. Unlike bench-top instruments, however, they critically require selectivity for the concerned species, because chemical sensors do not involve sample pretreatments such as separation. Selectivity may be obtained through the use of membranes, as has been shown for Nafion (perfluorosulphonated ionomer) coated glucose sensors intended for implantation in diabetic patients. Rotating disc electro-chemistry was used to measure the selectivity of Nafion to glucose and against interfering species. The effects of membrane preparation parameters, such as thickness, on selectivity have also been investigated.

ISBN: 0612112039Subjects--Topical Terms:

586156
Chemistry, Analytical.

Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors.
LDR:03156nam 2200289 a 45 001 937881
005 20110511
008 110511s1994 eng d
020 $a 0612112039
035 $a (UnM)AAINN11203
035 $a AAINN11203
040 $a UnM $c UnM
100 1 $a Fan, Zhonghui Hugh. $3 1261737
245 1 0 $a Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors.
300 $a 234 p.
500 $a Adviser: Jed Harrison.
500 $a Source: Dissertation Abstracts International, Volume: 57-08, Section: B, page: 5018.
502 $a Thesis (Ph.D.)--University of Alberta (Canada), 1994.
520 $a Chemical sensors have found considerable applications in biotechnology, process control, environmental and medical sciences, as they can be used to make measurements rapidly, repetitively, or even outside the lab. Unlike bench-top instruments, however, they critically require selectivity for the concerned species, because chemical sensors do not involve sample pretreatments such as separation. Selectivity may be obtained through the use of membranes, as has been shown for Nafion (perfluorosulphonated ionomer) coated glucose sensors intended for implantation in diabetic patients. Rotating disc electro-chemistry was used to measure the selectivity of Nafion to glucose and against interfering species. The effects of membrane preparation parameters, such as thickness, on selectivity have also been investigated.
520 $a An alternative approach to selectivity is to integrate separation techniques, such as capillary electrophoresis (CE), within a chemical sensor. Using integrated circuit fabrication technology called micromachining, micron-scale capillaries and sample injection systems have been fabricated in small glass chips, which resemble miniaturized instruments in terms of size and operations. Pumping of samples and mobile phase is performed electrokinetically by application of a high voltage. Electrophoresis, which occurs at the same time, effects the separation of components since they have different mobilities under an electric field. A laser-induced fluorescence detector is used for the detection. Three fluorophore tagged amino acids can be separated within 3 seconds in such a device. The configuration of the injectors demonstrated an influence on defining injected sample volume and separation efficiency. Leaking, or mixing, at the intersection increased the background and decreased the dynamic range of detection, but it can be suppressed by applying appropriate voltages to multiple reservoirs. A chamber integrated in a device has been used for mixing, suggesting sample pretreatment or post-column derivatization may be performed on such devices. These results, as well as linear calibration curves obtained over 3 orders of magnitude, indicate the potential of such devices for chemical analysis in the future.
590 $a School code: 0351.
650 4 $a Chemistry, Analytical. $3 586156
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0486
690 $a 0541
710 2 0 $a University of Alberta (Canada). $3 626651
773 0 $t Dissertation Abstracts International $g 57-08B.
790 $a 0351
790 1 0 $a Harrison, Jed, $e advisor
791 $a Ph.D.
792 $a 1994
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NN11203