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Micromachining, capillary electropho...

Fan, Zhonghui Hugh.

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Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors./
作者:	Fan, Zhonghui Hugh.
面頁冊數:	234 p.
附註:	Adviser: Jed Harrison.
Contained By:	Dissertation Abstracts International57-08B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NN11203
ISBN:	0612112039

Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors.
Fan, Zhonghui Hugh.

Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors. - 234 p.

Adviser: Jed Harrison.

Thesis (Ph.D.)--University of Alberta (Canada), 1994.

Chemical sensors have found considerable applications in biotechnology, process control, environmental and medical sciences, as they can be used to make measurements rapidly, repetitively, or even outside the lab. Unlike bench-top instruments, however, they critically require selectivity for the concerned species, because chemical sensors do not involve sample pretreatments such as separation. Selectivity may be obtained through the use of membranes, as has been shown for Nafion (perfluorosulphonated ionomer) coated glucose sensors intended for implantation in diabetic patients. Rotating disc electro-chemistry was used to measure the selectivity of Nafion to glucose and against interfering species. The effects of membrane preparation parameters, such as thickness, on selectivity have also been investigated.

ISBN: 0612112039Subjects--Topical Terms:

586156
Chemistry, Analytical.

Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors.
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100 1 $a Fan, Zhonghui Hugh. $3 1261737
245 1 0 $a Micromachining, capillary electrophoresis, polymers, and their applications to chemical sensors.
300 $a 234 p.
500 $a Adviser: Jed Harrison.
500 $a Source: Dissertation Abstracts International, Volume: 57-08, Section: B, page: 5018.
502 $a Thesis (Ph.D.)--University of Alberta (Canada), 1994.
520 $a Chemical sensors have found considerable applications in biotechnology, process control, environmental and medical sciences, as they can be used to make measurements rapidly, repetitively, or even outside the lab. Unlike bench-top instruments, however, they critically require selectivity for the concerned species, because chemical sensors do not involve sample pretreatments such as separation. Selectivity may be obtained through the use of membranes, as has been shown for Nafion (perfluorosulphonated ionomer) coated glucose sensors intended for implantation in diabetic patients. Rotating disc electro-chemistry was used to measure the selectivity of Nafion to glucose and against interfering species. The effects of membrane preparation parameters, such as thickness, on selectivity have also been investigated.
520 $a An alternative approach to selectivity is to integrate separation techniques, such as capillary electrophoresis (CE), within a chemical sensor. Using integrated circuit fabrication technology called micromachining, micron-scale capillaries and sample injection systems have been fabricated in small glass chips, which resemble miniaturized instruments in terms of size and operations. Pumping of samples and mobile phase is performed electrokinetically by application of a high voltage. Electrophoresis, which occurs at the same time, effects the separation of components since they have different mobilities under an electric field. A laser-induced fluorescence detector is used for the detection. Three fluorophore tagged amino acids can be separated within 3 seconds in such a device. The configuration of the injectors demonstrated an influence on defining injected sample volume and separation efficiency. Leaking, or mixing, at the intersection increased the background and decreased the dynamic range of detection, but it can be suppressed by applying appropriate voltages to multiple reservoirs. A chamber integrated in a device has been used for mixing, suggesting sample pretreatment or post-column derivatization may be performed on such devices. These results, as well as linear calibration curves obtained over 3 orders of magnitude, indicate the potential of such devices for chemical analysis in the future.
590 $a School code: 0351.
650 4 $a Chemistry, Analytical. $3 586156
650 4 $a Engineering, Biomedical. $3 1017684
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792 $a 1994
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