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Cryptochrome: A photoreceptor for no...

Thompson, Carol Lynn.

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Cryptochrome: A photoreceptor for nonvisual irradiance detection in mammals.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Cryptochrome: A photoreceptor for nonvisual irradiance detection in mammals./
Author:	Thompson, Carol Lynn.
Description:	194 p.
Notes:	Director: Aziz Sancar.
Contained By:	Dissertation Abstracts International64-03B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3086631

Cryptochrome: A photoreceptor for nonvisual irradiance detection in mammals.
Thompson, Carol Lynn.

Cryptochrome: A photoreceptor for nonvisual irradiance detection in mammals. - 194 p.

Director: Aziz Sancar.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2003.

Light regulates animal behavior through visual and nonvisual photoreceptive pathways. While vision is governed by the opsins in rod and cone photoreceptors of the mammalian retina, other nonvisual tasks, such as circadian entrainment and masking, appear to be mediated through multiple photoreceptors. Cryptochrome (Cry) is a blue-light photoreceptor present in the mammalian retina which is also an integral part of the circadian clock mechanism and functions alongside melanopsin and classical opsins to transmit light information to the brain, as assayed by both behavioral assays and molecular gene induction by light in the brain. Specifically, in this study, several mouse models have been used to explore the contribution of cryptochrome and opsins to circadian regulation and other nonvisual irradiance detection tasks, and include <italic>retinal degeneration</italic> (<italic>rd</italic>) mice, cryptochrome knockout mice (<italic>cry1−</italic>/<italic>−cry2−</italic>/<italic> −</italic>), plasma retinol binding protein knockout mice (<italic> rbp−</italic>/<italic>−</italic>), and combinations thereof. I have found that cryptochromes and opsins both contribute to molecular gene induction in the SCN through photoreception in the retina, and that only in the absence of both do animals become totally unresponsive to light. In addition, the action spectrum of circadian gene photoinduction in a non-retinal-derived embryonic cell line from zebrafish supports cryptochrome as the primary photoreceptor governing this response. The evidence to date indicates that both cryptochrome and opsin are sufficient but neither is essential for nonvisual photoresponses in mammals.Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Cryptochrome: A photoreceptor for nonvisual irradiance detection in mammals.
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035 $a (UnM)AAI3086631
035 $a AAI3086631
040 $a UnM $c UnM
100 1 $a Thompson, Carol Lynn. $3 1258441
245 1 0 $a Cryptochrome: A photoreceptor for nonvisual irradiance detection in mammals.
300 $a 194 p.
500 $a Director: Aziz Sancar.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1103.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2003.
520 $a Light regulates animal behavior through visual and nonvisual photoreceptive pathways. While vision is governed by the opsins in rod and cone photoreceptors of the mammalian retina, other nonvisual tasks, such as circadian entrainment and masking, appear to be mediated through multiple photoreceptors. Cryptochrome (Cry) is a blue-light photoreceptor present in the mammalian retina which is also an integral part of the circadian clock mechanism and functions alongside melanopsin and classical opsins to transmit light information to the brain, as assayed by both behavioral assays and molecular gene induction by light in the brain. Specifically, in this study, several mouse models have been used to explore the contribution of cryptochrome and opsins to circadian regulation and other nonvisual irradiance detection tasks, and include <italic>retinal degeneration</italic> (<italic>rd</italic>) mice, cryptochrome knockout mice (<italic>cry1−</italic>/<italic>−cry2−</italic>/<italic> −</italic>), plasma retinol binding protein knockout mice (<italic> rbp−</italic>/<italic>−</italic>), and combinations thereof. I have found that cryptochromes and opsins both contribute to molecular gene induction in the SCN through photoreception in the retina, and that only in the absence of both do animals become totally unresponsive to light. In addition, the action spectrum of circadian gene photoinduction in a non-retinal-derived embryonic cell line from zebrafish supports cryptochrome as the primary photoreceptor governing this response. The evidence to date indicates that both cryptochrome and opsin are sufficient but neither is essential for nonvisual photoresponses in mammals.
590 $a School code: 0153.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Chemistry, Biochemistry. $3 1017722
690 $a 0307
690 $a 0369
690 $a 0433
690 $a 0487
710 2 0 $a The University of North Carolina at Chapel Hill. $3 1017449
773 0 $t Dissertation Abstracts International $g 64-03B.
790 $a 0153
790 1 0 $a Sancar, Aziz, $e advisor
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3086631