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T-box transcription factor interacti...

Goering, Lisa Marie.

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T-box transcription factor interactions in the zebrafish mesoderm: Regulation of gene expression and cell fate.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	T-box transcription factor interactions in the zebrafish mesoderm: Regulation of gene expression and cell fate./
Author:	Goering, Lisa Marie.
Description:	146 p.
Notes:	Adviser: David J. Grunwald.
Contained By:	Dissertation Abstracts International64-03B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3084160

T-box transcription factor interactions in the zebrafish mesoderm: Regulation of gene expression and cell fate.
Goering, Lisa Marie.

T-box transcription factor interactions in the zebrafish mesoderm: Regulation of gene expression and cell fate. - 146 p.

Adviser: David J. Grunwald.

Thesis (Ph.D.)--The University of Utah, 2003.

T-box genes encode related transcription factors that regulate tissue specification and morphogenesis in vertebrates. Whereas individual T-box genes are commonly expressed across broad domains of precursor cells, phenotypic analyses of mutant embryos indicate that T-box genes often have regionally proscribed functions within their expression domains. As multiple T-box genes are often coexpressed within developmental fields, I propose that interactions among T-box genes may alter the activity of an individual T-box gene within a portion of its expression domain.Subjects--Topical Terms:

1017686
Biology, Cell.

T-box transcription factor interactions in the zebrafish mesoderm: Regulation of gene expression and cell fate.
LDR:03588nam 2200301 a 45 001 934740
005 20110509
008 110509s2003 eng d
035 $a (UnM)AAI3084160
035 $a AAI3084160
040 $a UnM $c UnM
100 1 $a Goering, Lisa Marie. $3 1258439
245 1 0 $a T-box transcription factor interactions in the zebrafish mesoderm: Regulation of gene expression and cell fate.
300 $a 146 p.
500 $a Adviser: David J. Grunwald.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1067.
502 $a Thesis (Ph.D.)--The University of Utah, 2003.
520 $a T-box genes encode related transcription factors that regulate tissue specification and morphogenesis in vertebrates. Whereas individual T-box genes are commonly expressed across broad domains of precursor cells, phenotypic analyses of mutant embryos indicate that T-box genes often have regionally proscribed functions within their expression domains. As multiple T-box genes are often coexpressed within developmental fields, I propose that interactions among T-box genes may alter the activity of an individual T-box gene within a portion of its expression domain.
520 $a The T-box genes <italic>no tail, spadetail</italic> and <italic>tbx6 </italic> are expressed in overlapping domains within the mesoderm of the zebrafish embryo, and regions marked by the coexpression of these genes correlate well with domains of known cell fate. Additionally, the phenotypes of <italic> no tail</italic> and <italic>spadetail</italic> mutants indicate that these broadly expressed genes have tissue-specific functions within their continuous expression domains. I hypothesized that in domains of coexpression, T-box genes may interact to direct the region-specific activities of an individual family member. I demonstrate that both No Tail and Spadetail regulate distinct target genes in subregions of their expression domains. Additionally, I show that interactions among the three T-box genes account for some of the region-specific functions of No Tail and Spadetail. These findings indicate that the mesoderm T-box genes function as an interacting network to direct region-specific gene expression and development.
520 $a The identified T-box gene interactions do not account for all the region-specific activities of <italic>spadetail</italic> and<italic> no tail</italic>. The expression of <italic>tbx6</italic> within the ventral mesoderm, for example, requires <italic>spadetail</italic> function; however, as <italic>spadetail </italic> is initially expressed throughout the entire mesoderm, there must be additional factors that limit the expression of <italic>tbx6</italic> to the ventral subdomain of the <italic>spadetail</italic> expression domain. Here I demonstrate that the correct expression of <italic>tbx6</italic> requires the combined functions of Spadetail and signaling through the BMP pathway. Thus, an interaction with the BMP pathway is an additional mechanism that directs the region-specific activities of a T-box transcription factor. Finally, I show that regulation of <italic>tbx6</italic> by Spadetail is direct and mediated through the interaction of Spadetail with a novel T-site motif present in the <italic>tbx6</italic> promoter.
590 $a School code: 0240.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
690 $a 0307
690 $a 0369
690 $a 0379
710 2 0 $a The University of Utah. $3 1017410
773 0 $t Dissertation Abstracts International $g 64-03B.
790 $a 0240
790 1 0 $a Grunwald, David J., $e advisor
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3084160