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Synthesis and studies of self-organi...

Chen, Ming-Hsiung.

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Synthesis and studies of self-organization of amphiphilic copolymers into nano-micellar particle by light scattering and (1)H-NMR relaxation.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Synthesis and studies of self-organization of amphiphilic copolymers into nano-micellar particle by light scattering and (1)H-NMR relaxation./
Author:	Chen, Ming-Hsiung.
Description:	139 p.
Notes:	Adviser: Arthur C. Watterson.
Contained By:	Dissertation Abstracts International64-03B.
Subject:	Chemistry, Physical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3083321

Synthesis and studies of self-organization of amphiphilic copolymers into nano-micellar particle by light scattering and (1)H-NMR relaxation.
Chen, Ming-Hsiung.

Synthesis and studies of self-organization of amphiphilic copolymers into nano-micellar particle by light scattering and (1)H-NMR relaxation. - 139 p.

Adviser: Arthur C. Watterson.

Thesis (Ph.D.)--University of Massachusetts Lowell, 2003.

This thesis includes five portions i.e. the background and introduction, the chapter of the synthesis, the chapter of the measurement using <super> 1</super>H-NMR relaxation time, the chapter of the measurement using light scattering, and the conclusion. In the first portion, we introduced the fundamental principles that regard with our system i.e. nano-micellar particles based on polyethylene glycol (PEG)-based amphiphilic copolymers, and the techniques that used to measure the properties of the particles.Subjects--Topical Terms:

560527
Chemistry, Physical.

Synthesis and studies of self-organization of amphiphilic copolymers into nano-micellar particle by light scattering and (1)H-NMR relaxation.
LDR:03583nam 2200301 a 45 001 934701
005 20110509
008 110509s2003 eng d
035 $a (UnM)AAI3083321
035 $a AAI3083321
040 $a UnM $c UnM
100 1 $a Chen, Ming-Hsiung. $3 1258400
245 1 0 $a Synthesis and studies of self-organization of amphiphilic copolymers into nano-micellar particle by light scattering and (1)H-NMR relaxation.
300 $a 139 p.
500 $a Adviser: Arthur C. Watterson.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1269.
502 $a Thesis (Ph.D.)--University of Massachusetts Lowell, 2003.
520 $a This thesis includes five portions i.e. the background and introduction, the chapter of the synthesis, the chapter of the measurement using <super> 1</super>H-NMR relaxation time, the chapter of the measurement using light scattering, and the conclusion. In the first portion, we introduced the fundamental principles that regard with our system i.e. nano-micellar particles based on polyethylene glycol (PEG)-based amphiphilic copolymers, and the techniques that used to measure the properties of the particles.
520 $a The preparations of the copolymers were explained in Chapter 2, which reports the synthesis of a number of functional monomers including 2-(8-bromooctoxy) tetrahydropyran, 12-bromo-1-t-butoxydodecane, and 12-bromo-1-(monomethoxytrityloxy)dodecane from 12-bromooctanol, which is commercially available. These functional monomers were then used to polymerize with poly(ethylene glycol) using dibutyltin diacetate as catalyst. During chemical polymerization of these functionalized monomers with poly(ethylene glycol) insoluble gel like product was obtained.
520 $a Chapter 3 reports the studied about the aggregation or micellization of the non-functionalized PEG-based amphiphilic copolymer using <super>1</super>H-NMR relaxation time. From that experiment, the aggregation behavior of the copolymers in different solvents was studied so that a logical model of the micellar particles in aqueous solution was built. This experiment provided a genuine way to discover the influences of aggregation or micellization of the copolymers in different solvents on changing the local environments of the protons physically. This might become an effective method to monitor the influences of structural modifications such as adding functional group onto the hydrophobic segments on the formation of micellar particles.
520 $a Chapter 4 reports the experiments that measure the micellar particular properties such as the size, the shape, the aggregation number, and the critical micelle concentration (CMC) of copolymers in water using light scattering technique, which was carefully tested and evaluated before using. The CMC was evaluated as c.a. 0.6 to 0.7 mg/ml. The sizes (root-mean-square-radius) of our micellar particles are in the range of c.a. 17 to 30 nanometers. They were found proportional to the chain length of the PEG that used to form the copolymers and strongly influenced by the functionalization of the hydrophobic segments. The sizes of the particles that encapsulate a variety of drugs were also measured, which were highly depended on the functionalization of the hydrophobic side chains.
590 $a School code: 0111.
650 4 $a Chemistry, Physical. $3 560527
650 4 $a Chemistry, Polymer. $3 1018428
690 $a 0494
690 $a 0495
710 2 0 $a University of Massachusetts Lowell. $3 1017839
773 0 $t Dissertation Abstracts International $g 64-03B.
790 $a 0111
790 1 0 $a Watterson, Arthur C., $e advisor
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3083321