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Correlates of low-density lipoprotei...

Maki, Kevin Carl.

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Correlates of low-density lipoprotein phenotype B in postmenopausal women.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Correlates of low-density lipoprotein phenotype B in postmenopausal women./
Author:	Maki, Kevin Carl.
Description:	107 p.
Notes:	Adviser: Rebecca Lipton.
Contained By:	Dissertation Abstracts International60-12B.
Subject:	Health Sciences, Human Development. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9954830
ISBN:	0599580283

Correlates of low-density lipoprotein phenotype B in postmenopausal women.
Maki, Kevin Carl.

Correlates of low-density lipoprotein phenotype B in postmenopausal women. - 107 p.

Adviser: Rebecca Lipton.

Thesis (Ph.D.)--University of Illinois at Chicago, 1999.

Low density lipoprotein (LDL) subclass pattern B, a predominance of small, dense LDL particles, has been associated with a 2- to 3-fold increase in coronary-heart disease risk. The present work reports resulted from studies investigating the association between LDL subclass pattern B and hyperfibrinogenemia, as well as the impact of LDL subclass pattern on the relationship between measures of adiposity and the circulating lipoprotein profile. The study sample for these investigations comprised 270 postmenopausal women, 70 years of age or less, who were not taking sex hormone replacement at the time the measurements were obtained. The crude odds ratio for LDL subclass pattern B among postmenopausal women with fibrinogen in the top tertile (≥354 mg/dL) was 2.03 (95% CI 1.18–3.51). This association retained statistical significance after adjustment for numerous potential confounders. In the final logistic regression model, which included 17 covariates, the adjusted odds ratio was 2.56 (95% CI 1.27–5.27), consistent with the possibility that elevated fibrinogen contributes to the increased coronary heart disease risk associated with the pattern B phenotype. LDL subclass pattern B was also associated with significantly higher triglyceride and lower HDL cholesterol concentrations at any level of adiposity. Although the tests for multiplicative interaction did not reach statistical significance, clear trends were present toward steeper slopes for the regression lines relating indicators of adiposity to triglyceride and HDL cholesterol levels among women with the pattern B phenotype compared to those without pattern B. These results suggest that women with the pattern B phenotype may experience a greater worsening of the cardiovascular risk profile with increasing adiposity, and conversely, might be expected to derive greater benefit from loss of excess body fat. A review of the published data indicates that lipid and lipoprotein responses differ by LDL subclass distribution pattern for a number of therapies including niacin, colestipol, dietary modification, and weight loss. Taken together, the results support the concept that LDL subclass pattern B is a marker for multiple potentially atherogenic metabolic disturbances.

ISBN: 0599580283Subjects--Topical Terms:

1019218
Health Sciences, Human Development.

Correlates of low-density lipoprotein phenotype B in postmenopausal women.
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500 $a Source: Dissertation Abstracts International, Volume: 60-12, Section: B, page: 6059.
502 $a Thesis (Ph.D.)--University of Illinois at Chicago, 1999.
520 $a Low density lipoprotein (LDL) subclass pattern B, a predominance of small, dense LDL particles, has been associated with a 2- to 3-fold increase in coronary-heart disease risk. The present work reports resulted from studies investigating the association between LDL subclass pattern B and hyperfibrinogenemia, as well as the impact of LDL subclass pattern on the relationship between measures of adiposity and the circulating lipoprotein profile. The study sample for these investigations comprised 270 postmenopausal women, 70 years of age or less, who were not taking sex hormone replacement at the time the measurements were obtained. The crude odds ratio for LDL subclass pattern B among postmenopausal women with fibrinogen in the top tertile (≥354 mg/dL) was 2.03 (95% CI 1.18–3.51). This association retained statistical significance after adjustment for numerous potential confounders. In the final logistic regression model, which included 17 covariates, the adjusted odds ratio was 2.56 (95% CI 1.27–5.27), consistent with the possibility that elevated fibrinogen contributes to the increased coronary heart disease risk associated with the pattern B phenotype. LDL subclass pattern B was also associated with significantly higher triglyceride and lower HDL cholesterol concentrations at any level of adiposity. Although the tests for multiplicative interaction did not reach statistical significance, clear trends were present toward steeper slopes for the regression lines relating indicators of adiposity to triglyceride and HDL cholesterol levels among women with the pattern B phenotype compared to those without pattern B. These results suggest that women with the pattern B phenotype may experience a greater worsening of the cardiovascular risk profile with increasing adiposity, and conversely, might be expected to derive greater benefit from loss of excess body fat. A review of the published data indicates that lipid and lipoprotein responses differ by LDL subclass distribution pattern for a number of therapies including niacin, colestipol, dietary modification, and weight loss. Taken together, the results support the concept that LDL subclass pattern B is a marker for multiple potentially atherogenic metabolic disturbances.
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