東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Effects of sex steroids and diet on ...

Shultz, Jennifer Marie.

Linked to FindBook

Google Book

Amazon

博客來

Effects of sex steroids and diet on adipose distribution and cardiovascular disease risk factors.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effects of sex steroids and diet on adipose distribution and cardiovascular disease risk factors./
Author:	Shultz, Jennifer Marie.
Description:	141 p.
Notes:	Chair: Michael E. Rosenfeld.
Contained By:	Dissertation Abstracts International63-01B.
Subject:	Health Sciences, Medicine and Surgery. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3041057
ISBN:	0493544887

Effects of sex steroids and diet on adipose distribution and cardiovascular disease risk factors.
Shultz, Jennifer Marie.

Effects of sex steroids and diet on adipose distribution and cardiovascular disease risk factors. - 141 p.

Chair: Michael E. Rosenfeld.

Thesis (Ph.D.)--University of Washington, 2002.

Cardiovascular disease risk increases in women after menopause, coincident with increases in low-density lipoprotein cholesterol levels (1). While loss of estrogen results in lower LDL and higher HDL levels, estrogen loss also favors visceral adipose deposition (2). My aim was to investigate the potential of hormone replacement therapy in ameliorating many of these cardiovascular disease risk factors, and to determine how diet may influence these interactions.

ISBN: 0493544887Subjects--Topical Terms:

1017756
Health Sciences, Medicine and Surgery.

Effects of sex steroids and diet on adipose distribution and cardiovascular disease risk factors.
LDR:03417nam 2200313 a 45 001 929432
005 20110427
008 110427s2002 eng d
020 $a 0493544887
035 $a (UnM)AAI3041057
035 $a AAI3041057
040 $a UnM $c UnM
100 1 $a Shultz, Jennifer Marie. $3 1252918
245 1 0 $a Effects of sex steroids and diet on adipose distribution and cardiovascular disease risk factors.
300 $a 141 p.
500 $a Chair: Michael E. Rosenfeld.
500 $a Source: Dissertation Abstracts International, Volume: 63-01, Section: B, page: 0187.
502 $a Thesis (Ph.D.)--University of Washington, 2002.
520 $a Cardiovascular disease risk increases in women after menopause, coincident with increases in low-density lipoprotein cholesterol levels (1). While loss of estrogen results in lower LDL and higher HDL levels, estrogen loss also favors visceral adipose deposition (2). My aim was to investigate the potential of hormone replacement therapy in ameliorating many of these cardiovascular disease risk factors, and to determine how diet may influence these interactions.
520 $a To investigate the effects of estrogen and estrogen/progestin combinations on the development of atherosclerosis, apolipoprotein E knockout (apoE KO) mice received either a sham operation + placebo pellet or a bilateral ovariectomy + 1 of 9 combination estrogen/progestin hormone pellets. After 8 weeks of treatment, all hormone treatment groups had significantly smaller lesion sizes than untreated groups. Hormone treatment also suppressed ovariectomy-induced gain in adipose depot mass.
520 $a Next, I investigated whether ovariectomy-induced obesity, in conjunction with a high fat, high sucrose (HFHS) diet, could be ameliorated by HRT. First, I determined that the C57BL/6J mouse was an appropriate model for diet-induced, visceral obesity. C57BL/6J mice were then sham-operated or ovariectomized and administered placebo, estrogen alone, or combined hormone replacement therapy. Chow-fed animals administered estrogen had a greater percentage of subcutaneous adipose versus visceral adipose than untreated animals. HFHS-fed animals administered combined hormone therapy had significantly greater body weight gain and greater adipose depot weights than sham-operated and estrogen-treated animals, and had less percentage of subcutaneous adipose than estrogen-treated animals.
520 $a Finally, I determined whether obesity could be ameliorated by the estrogen-like soy isoflavone genistein. An additional group of sham-operated and ovariectomized animals received dietary genistein in lieu of the hormone pellets. Significant differences were only seen in animals fed the HFHS diet: genistein treatment resulted in less body weight change and less adipose depot mass compared to groups that did not receive genistein. In summary, genetic and dietary differences influenced the cardioprotective effects of sex hormones in this study. Future research needs to address the mechanisms by which genistein suppresses adipose gain, and needs to examine whether genistein inhibits lesion development in these mice.
590 $a School code: 0250.
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0564
690 $a 0570
710 2 0 $a University of Washington. $3 545923
773 0 $t Dissertation Abstracts International $g 63-01B.
790 $a 0250
790 1 0 $a Rosenfeld, Michael E., $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3041057