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Effect of epinephrine on net lactate...

Hamann, Jason J.

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Effect of epinephrine on net lactate uptake by contracting skeletal muscle.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Effect of epinephrine on net lactate uptake by contracting skeletal muscle./
作者:	Hamann, Jason J.
面頁冊數:	119 p.
附註:	Director: L. Bruce Gladden.
Contained By:	Dissertation Abstracts International61-03B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9965733
ISBN:	0599703326

Effect of epinephrine on net lactate uptake by contracting skeletal muscle.
Hamann, Jason J.

Effect of epinephrine on net lactate uptake by contracting skeletal muscle. - 119 p.

Director: L. Bruce Gladden.

Thesis (Ph.D.)--Auburn University, 2000.

The purpose of this study was to determine the effect of epinephrine on net lactate uptake at constant elevated blood lactate concentration and steady level metabolic rate (V&dot;o2) in the canine gastrocnemius-plantaris (GP) muscle <italic>in situ</italic>. Infusion of lactate/lactic acid at a pH of 3.5 established a mean arterial blood lactate concentration of &sim;10 mM while maintaining normal blood gas and pH status as the GP was stimulated with tetanic trains at a rate of one contraction every four seconds. Following steady state control measures, epinephrine was infused for 35 minutes at rates that would produce a high physiological concentration with (PRO) (n = 6) and without (EPI) (n = 6) β-adrenergic receptor blockade via propranolol. Net lactate uptake values during the control conditions were not significantly different between trials, 0.756 ± 0.043 and 0.703 ± 0.061 mmol • kg<super>-1</super> • min<super>-1</super> for EPI and PRO, respectively. Steady level V&dot;o2 averaged &sim;69.5 ml • kg<super>-1</super> • min<super>-1</super> for both control conditions and did not significantly change over the course of the experiments in either set of trials. The EPI experiments resulted in a significantly reduced net lactate uptake as compared to the control value at all sample times measured. However, net lactate uptake was not significantly different from control at any time during PRO. When the change from the respective control values for net lactate uptake were compared across time for both series of experiments, EPI resulted in a significantly greater change from the control than did PRO. This study suggests that epinephrine can have a profound effect on net lactate uptake by contracting muscle and that these effects are elicited through β-adrenergic receptor stimulation.

ISBN: 0599703326Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Effect of epinephrine on net lactate uptake by contracting skeletal muscle.
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245 1 0 $a Effect of epinephrine on net lactate uptake by contracting skeletal muscle.
300 $a 119 p.
500 $a Director: L. Bruce Gladden.
500 $a Source: Dissertation Abstracts International, Volume: 61-03, Section: B, page: 1334.
502 $a Thesis (Ph.D.)--Auburn University, 2000.
520 $a The purpose of this study was to determine the effect of epinephrine on net lactate uptake at constant elevated blood lactate concentration and steady level metabolic rate (V&dot;o2) in the canine gastrocnemius-plantaris (GP) muscle <italic>in situ</italic>. Infusion of lactate/lactic acid at a pH of 3.5 established a mean arterial blood lactate concentration of &sim;10 mM while maintaining normal blood gas and pH status as the GP was stimulated with tetanic trains at a rate of one contraction every four seconds. Following steady state control measures, epinephrine was infused for 35 minutes at rates that would produce a high physiological concentration with (PRO) (n = 6) and without (EPI) (n = 6) β-adrenergic receptor blockade via propranolol. Net lactate uptake values during the control conditions were not significantly different between trials, 0.756 ± 0.043 and 0.703 ± 0.061 mmol • kg<super>-1</super> • min<super>-1</super> for EPI and PRO, respectively. Steady level V&dot;o2 averaged &sim;69.5 ml • kg<super>-1</super> • min<super>-1</super> for both control conditions and did not significantly change over the course of the experiments in either set of trials. The EPI experiments resulted in a significantly reduced net lactate uptake as compared to the control value at all sample times measured. However, net lactate uptake was not significantly different from control at any time during PRO. When the change from the respective control values for net lactate uptake were compared across time for both series of experiments, EPI resulted in a significantly greater change from the control than did PRO. This study suggests that epinephrine can have a profound effect on net lactate uptake by contracting muscle and that these effects are elicited through β-adrenergic receptor stimulation.
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