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The effect of vitamin C supplementat...

Timmer, Jeffrey Michael.

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The effect of vitamin C supplementation on serum free radical levels and delayed-onset muscle soreness following an acute bout of resistive exercise.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The effect of vitamin C supplementation on serum free radical levels and delayed-onset muscle soreness following an acute bout of resistive exercise./
Author:	Timmer, Jeffrey Michael.
Description:	91 p.
Notes:	Adviser: Fredric L. Goss.
Contained By:	Dissertation Abstracts International63-05A.
Subject:	Chemistry, Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3054348
ISBN:	0493696741

The effect of vitamin C supplementation on serum free radical levels and delayed-onset muscle soreness following an acute bout of resistive exercise.
Timmer, Jeffrey Michael.

The effect of vitamin C supplementation on serum free radical levels and delayed-onset muscle soreness following an acute bout of resistive exercise. - 91 p.

Adviser: Fredric L. Goss.

Thesis (Ph.D.)--University of Pittsburgh, 2002.

An increase in free radical production and serum concentration leads to lipid peroxidation in active tissue following exercise, which may contribute to delayed onset muscle soreness (DOMS). Antioxidant supplementation may reduce free radical levels, thereby attenuating the intensity of DOMS. Therefore, the purposes of this investigation were: (1) To determine the effects of Vitamin C supplementation on serum malondialdehyde concentration (MDA) and DOMS following an acute bout of high intensity whole body resistance exercise and (2) to determine if there is a relation between DOMS and MDA concentration following resistance exercise. Ten untrained males (20.5 ± 3.2 yr) that did not have resistance exercise experience and did not use supplements in the past year participated in this investigation. Subjects were randomly assigned to a double blind counterbalanced supplementation sequence (Vitamin C and placebo). All subjects completed an eight-exercise circuit resistance exercise protocol consisting of three sets of ten repetitions at 73.5% of one repetition maximum for each exercise under each supplement condition. Blood samples and measures of active and passive muscle soreness were obtained before exercise (BE), immediately post-exercise (IPE), 6hr PE, 24hr PE, and 48hr PE. Plasma ascorbic acid (umol/l) was higher BE (73.3 ± 29.4 vs. 13.8 ± 7.8, p < 0.01) and 24hr PE (49.6 ± 23.0 vs. 18.5 ± 9.6, p < 0.05) in the Vitamin C supplementation condition. However, there was no difference between the Vitamin C and placebo groups for MDA concentration (nmol/L) or DOMS at any timepoint. At 24hr PE, MDA levels (2.9 ± 0.6) were greater (p < 0.05) than BE levels (2.5 ± 0.5). A time main effect was observed for all measures of muscle soreness. Muscle soreness was greater (p < 0.01) at IPE, 6hr PE, 24hr PE, and 48hr PE compared to BE levels. No relation was found between MDA concentration and any measure of muscle soreness (r = −0.06 to −0.10). This study showed that high intensity whole body resistance exercise significantly increases MDA concentration 24hr PE. However, this study showed that Vitamin C supplementation was ineffective at attenuating the rise in MDA concentration and DOMS. Finally, a weak correlation between MDA concentration and DOMS was noted.

ISBN: 0493696741Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

The effect of vitamin C supplementation on serum free radical levels and delayed-onset muscle soreness following an acute bout of resistive exercise.
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245 1 0 $a The effect of vitamin C supplementation on serum free radical levels and delayed-onset muscle soreness following an acute bout of resistive exercise.
300 $a 91 p.
500 $a Adviser: Fredric L. Goss.
500 $a Source: Dissertation Abstracts International, Volume: 63-05, Section: A, page: 1767.
502 $a Thesis (Ph.D.)--University of Pittsburgh, 2002.
520 $a An increase in free radical production and serum concentration leads to lipid peroxidation in active tissue following exercise, which may contribute to delayed onset muscle soreness (DOMS). Antioxidant supplementation may reduce free radical levels, thereby attenuating the intensity of DOMS. Therefore, the purposes of this investigation were: (1) To determine the effects of Vitamin C supplementation on serum malondialdehyde concentration (MDA) and DOMS following an acute bout of high intensity whole body resistance exercise and (2) to determine if there is a relation between DOMS and MDA concentration following resistance exercise. Ten untrained males (20.5 ± 3.2 yr) that did not have resistance exercise experience and did not use supplements in the past year participated in this investigation. Subjects were randomly assigned to a double blind counterbalanced supplementation sequence (Vitamin C and placebo). All subjects completed an eight-exercise circuit resistance exercise protocol consisting of three sets of ten repetitions at 73.5% of one repetition maximum for each exercise under each supplement condition. Blood samples and measures of active and passive muscle soreness were obtained before exercise (BE), immediately post-exercise (IPE), 6hr PE, 24hr PE, and 48hr PE. Plasma ascorbic acid (umol/l) was higher BE (73.3 ± 29.4 vs. 13.8 ± 7.8, p < 0.01) and 24hr PE (49.6 ± 23.0 vs. 18.5 ± 9.6, p < 0.05) in the Vitamin C supplementation condition. However, there was no difference between the Vitamin C and placebo groups for MDA concentration (nmol/L) or DOMS at any timepoint. At 24hr PE, MDA levels (2.9 ± 0.6) were greater (p < 0.05) than BE levels (2.5 ± 0.5). A time main effect was observed for all measures of muscle soreness. Muscle soreness was greater (p < 0.01) at IPE, 6hr PE, 24hr PE, and 48hr PE compared to BE levels. No relation was found between MDA concentration and any measure of muscle soreness (r = −0.06 to −0.10). This study showed that high intensity whole body resistance exercise significantly increases MDA concentration 24hr PE. However, this study showed that Vitamin C supplementation was ineffective at attenuating the rise in MDA concentration and DOMS. Finally, a weak correlation between MDA concentration and DOMS was noted.
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