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The role of nitric oxide synthase in...

Smith, Lori Wynne.

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The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload./
作者:	Smith, Lori Wynne.
面頁冊數:	97 p.
附註:	Adviser: David Criswell.
Contained By:	Masters Abstracts International40-02.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1406069
ISBN:	0493349197

The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload.
Smith, Lori Wynne.

The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload. - 97 p.

Adviser: David Criswell.

Thesis (M.S.)--Texas Woman's University, 2001.

This study determined the necessity of nitric oxide (NO) for hypertrophy and fiber type transition in overloaded (OL) skeletal muscle. Endogenous NO production was blocked by N-nitro-L-arginine methyl ester (L-NAME; 0.75 mg/ml; &sim;100mg/kg/day) in drinking water. Thirty-eight female Sprague-Dawley rats (&sim;250g) were randomly divided into four groups: Control-NonOL, Control-OL, L-NAME-NonOL, and L-NAME-OL. Chronic overload of the plantaris was induced bilaterally by surgical removal of the gastrocnemius and soleus. L-NAME treatment began 24 hrs before surgery and continued through the 14-day OL period. Although OL induced hypertrophy in both Control (+80%) and L-NAME (+48%) conditions (P < 0.05), mean plantaris mass in the L-NAME-OL group was lower (P < 0.05) than the Control-OL group. SDS-PAGE analysis of myosin heavy chain (MHC) composition indicated an (P < 0.05) OL-effect in the Control rats. Specifically, the mean proportion of type I MHC increased 6% (P < 0.05) while type IIb MHC decreased &sim;9% (P < 0.05). No significant OL effects on MHC profile were observed in the L-NAME rats. These data support a role of NO in overload-induced skeletal muscle hypertrophy and fiber type transition.

ISBN: 0493349197Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The role of nitric oxide synthase in skeletal muscle adaptations to chronic overload.
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520 $a This study determined the necessity of nitric oxide (NO) for hypertrophy and fiber type transition in overloaded (OL) skeletal muscle. Endogenous NO production was blocked by N-nitro-L-arginine methyl ester (L-NAME; 0.75 mg/ml; &sim;100mg/kg/day) in drinking water. Thirty-eight female Sprague-Dawley rats (&sim;250g) were randomly divided into four groups: Control-NonOL, Control-OL, L-NAME-NonOL, and L-NAME-OL. Chronic overload of the plantaris was induced bilaterally by surgical removal of the gastrocnemius and soleus. L-NAME treatment began 24 hrs before surgery and continued through the 14-day OL period. Although OL induced hypertrophy in both Control (+80%) and L-NAME (+48%) conditions (P < 0.05), mean plantaris mass in the L-NAME-OL group was lower (P < 0.05) than the Control-OL group. SDS-PAGE analysis of myosin heavy chain (MHC) composition indicated an (P < 0.05) OL-effect in the Control rats. Specifically, the mean proportion of type I MHC increased 6% (P < 0.05) while type IIb MHC decreased &sim;9% (P < 0.05). No significant OL effects on MHC profile were observed in the L-NAME rats. These data support a role of NO in overload-induced skeletal muscle hypertrophy and fiber type transition.
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