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Stem cells and Hedgehog signals in m...

Santos, Miguel Ramalho.

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Stem cells and Hedgehog signals in mouse development.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Stem cells and Hedgehog signals in mouse development./
Author:	Santos, Miguel Ramalho.
Description:	160 p.
Notes:	Advisers: Douglas Melton; Andrew McMahon.
Contained By:	Dissertation Abstracts International63-04B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3051280
ISBN:	0493658548

Stem cells and Hedgehog signals in mouse development.
Santos, Miguel Ramalho.

Stem cells and Hedgehog signals in mouse development. - 160 p.

Advisers: Douglas Melton; Andrew McMahon.

Thesis (Ph.D.)--Harvard University, 2002.

In Part III, which is comprised of Chapter 4, I propose a theoretical framework for stem cell biology based on the concepts of autopoiesis and complementarity.

ISBN: 0493658548Subjects--Topical Terms:

1017686
Biology, Cell.

Stem cells and Hedgehog signals in mouse development.
LDR:02269nam 2200337 a 45 001 927769
005 20110425
008 110425s2002 eng d
020 $a 0493658548
035 $a (UnM)AAI3051280
035 $a AAI3051280
040 $a UnM $c UnM
100 1 $a Santos, Miguel Ramalho. $3 1251332
245 1 0 $a Stem cells and Hedgehog signals in mouse development.
300 $a 160 p.
500 $a Advisers: Douglas Melton; Andrew McMahon.
500 $a Source: Dissertation Abstracts International, Volume: 63-04, Section: B, page: 1711.
502 $a Thesis (Ph.D.)--Harvard University, 2002.
520 $a In Part III, which is comprised of Chapter 4, I propose a theoretical framework for stem cell biology based on the concepts of autopoiesis and complementarity.
520 $a Part I of this thesis, which is comprised of Chapter 1, describes the transcriptional profiling of mouse embryonic, hematopoietic and neural stem cells using microarrays, as an approach to identifying genes and functions common to all stem cells.
520 $a In the work that led to this Ph.D. thesis, I focused on two central questions in developmental biology: what does it mean to be an undifferentiated stem cell, and how does cell communication lead to pattern formation and differentiation. I used the mouse as organism of study for two main reasons: first, several types of stem cells can readily be isolated from mice; second, powerful tools are available in the mouse for genetic analyses of cell communication.
520 $a Part II reports essential roles of the Hedgehog cell signaling pathway in mouse embryogenesis. Chapter 2 describes a requirement for Hedgehog signaling in establishment of the L/R axis, and in somite and heart development. Chapter 3 describes results showing that Hedgehog signaling is essential for proper anterior/posterior and radial patterning of the gut, and for epithelial stem cell proliferation and differentiation.
590 $a School code: 0084.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
690 $a 0307
690 $a 0369
690 $a 0379
710 2 0 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 63-04B.
790 $a 0084
790 1 0 $a McMahon, Andrew, $e advisor
790 1 0 $a Melton, Douglas, $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3051280