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New insights on the regulation of ma...

Radosevich, Michael Donald.

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New insights on the regulation of major histocompatibility complex class II genes.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	New insights on the regulation of major histocompatibility complex class II genes./
Author:	Radosevich, Michael Donald.
Description:	208 p.
Notes:	Adviser: Santa Ono.
Contained By:	Dissertation Abstracts International63-04B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3051268
ISBN:	0493658424

New insights on the regulation of major histocompatibility complex class II genes.
Radosevich, Michael Donald.

New insights on the regulation of major histocompatibility complex class II genes. - 208 p.

Adviser: Santa Ono.

Thesis (Ph.D.)--Harvard University, 2002.

The regulation of major histocompatibility complex class II (MHC-II) gene expression plays an important role in the generation of the immune response. The MHC-II genes were first described as immune response (Ir) genes that produced high and low immune responses to certain antigens. The MHC was first identified because of its effect on skin and tumor transplantation. Since their discovery, much has been learned about the function and diversity of the MHC-II molecules.

ISBN: 0493658424Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

New insights on the regulation of major histocompatibility complex class II genes.
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020 $a 0493658424
035 $a (UnM)AAI3051268
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040 $a UnM $c UnM
100 1 $a Radosevich, Michael Donald. $3 1251330
245 1 0 $a New insights on the regulation of major histocompatibility complex class II genes.
300 $a 208 p.
500 $a Adviser: Santa Ono.
500 $a Source: Dissertation Abstracts International, Volume: 63-04, Section: B, page: 1777.
502 $a Thesis (Ph.D.)--Harvard University, 2002.
520 $a The regulation of major histocompatibility complex class II (MHC-II) gene expression plays an important role in the generation of the immune response. The MHC-II genes were first described as immune response (Ir) genes that produced high and low immune responses to certain antigens. The MHC was first identified because of its effect on skin and tumor transplantation. Since their discovery, much has been learned about the function and diversity of the MHC-II molecules.
520 $a The studies described in the following thesis investigated three important topics in MHC class II gene regulation. First, we examined the expression of class II molecules on ocular melanoma cells. We specifically focused on the melanoma 202 cell line. These cells were chosen because they are not able to induce class II molecules on the cell surface when stimulated with interferon-gamma. It is known that the majority of ocular melanoma cell lines cannot be induced to express class II on the cell surface when stimulated with interferon-gamma. We have demonstrated that this lack of induction is due to the inability of the cells to express CIITA.
520 $a Secondly, melanoma 202 cells along with two other ocular melanoma cell lines were examined in order to determine the mechanism for the repression of CIITA. It was determined that methylation is responsible for the repression of CIITA. When the cells were treated with a demethylating agent and then stimulated with interferon-gamma, class II molecules could be induced. We also provide evidence that the mechanism of suppression is different in ocular melanoma cells than in the previously described trophoblast cells which are also from an immune privileged site.
520 $a Lastly, we examined the induction of class II molecules in a CIITA independent manner on the surface of respiratory epithelial cells upon infection with the HPIV3 virus. The most widely publicized system for studying CIITA independent gene regulation is the induction of HLA-DR on the surface of cells derived from the human respiratory epithelium. Our findings show that, contrary to the previous reports, class II is not actually upregulated in these cells. The observed induction is simply due to an effect that the virus has on the infected cells which makes it appear as if class II is strongly induced. Therefore, other researchers should not use this system as a model to study CIITA independent class II gene regulation.
590 $a School code: 0084.
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0982
710 2 0 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 63-04B.
790 $a 0084
790 1 0 $a Ono, Santa, $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3051268