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VNO axonal projection to the posteri...

Chang, Ernie Chijon.

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VNO axonal projection to the posterior accessory olfactory bulb: Implications for pheromone sensory coding.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	VNO axonal projection to the posterior accessory olfactory bulb: Implications for pheromone sensory coding./
Author:	Chang, Ernie Chijon.
Description:	115 p.
Notes:	Adviser: Catherine Dulac.
Contained By:	Dissertation Abstracts International63-04B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3051123
ISBN:	049365559X

VNO axonal projection to the posterior accessory olfactory bulb: Implications for pheromone sensory coding.
Chang, Ernie Chijon.

VNO axonal projection to the posterior accessory olfactory bulb: Implications for pheromone sensory coding. - 115 p.

Adviser: Catherine Dulac.

Thesis (Ph.D.)--Harvard University, 2002.

The family of pheromone receptors, V2R, is expressed in the vomeronasal organ (VNO) of mice and rats and is thought to mediate pheromone responses. In rats, different V2R transcripts are expressed in spatially restricted zones of the VNO neuroepithelium of specific concentric radii. In the rat one receptor transcript shows a sexually dimorphic expression pattern. Although the purpose of these zones is unknown, their organization similar to that of other chemosensory systems suggests a functional significance. In order to perform a genetic analysis of the organization of receptor expression patterns and of the neuronal projections to the accessory olfactory bulb (AOB), I have analyzed the mouse V2R repertoire and identified 4 receptor sub-families. Receptors belonging to three of the sub-families are expressed by a random subset of VNO neurons, while receptors from one of the sub-families are expressed primarily by neurons located in the most basal portion of the neuroepithelium. Eighty percent of the newly identified V2Rs appear to encode non-functional proteins. In order to determine if the zones of V2R expression have a functional significance in the process of pheromone coding, the projection patterns of neurons expressing two specific V2Rs were analyzed in transgenic mouse lines generated with modified BACs. Two distinct patterns appear: neurons expressing a receptor with a basal expression pattern project to only one or a few glomeruli in a central portion of the posterior AOB, while neurons expressing a randomly distributed V2R project to multiple glomeruli within two large domains of stereotyped position in the posterior AOB. The organization of projection patterns does not appear to change during the course of development and is similar in both sexes. Finally, a rat V2R that displays a sexually dimorphic expression pattern was mis-expressed in transgenic mice constructed from a modified rat BAC. In these mice, neurons expressing the transgene do not display a sexually dimorphic expression pattern in the neuroepithelium, and their axons fail to project to defined glomeruli.

ISBN: 049365559XSubjects--Topical Terms:

1017730
Biology, Genetics.

VNO axonal projection to the posterior accessory olfactory bulb: Implications for pheromone sensory coding.
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100 1 $a Chang, Ernie Chijon. $3 1251291
245 1 0 $a VNO axonal projection to the posterior accessory olfactory bulb: Implications for pheromone sensory coding.
300 $a 115 p.
500 $a Adviser: Catherine Dulac.
500 $a Source: Dissertation Abstracts International, Volume: 63-04, Section: B, page: 1693.
502 $a Thesis (Ph.D.)--Harvard University, 2002.
520 $a The family of pheromone receptors, V2R, is expressed in the vomeronasal organ (VNO) of mice and rats and is thought to mediate pheromone responses. In rats, different V2R transcripts are expressed in spatially restricted zones of the VNO neuroepithelium of specific concentric radii. In the rat one receptor transcript shows a sexually dimorphic expression pattern. Although the purpose of these zones is unknown, their organization similar to that of other chemosensory systems suggests a functional significance. In order to perform a genetic analysis of the organization of receptor expression patterns and of the neuronal projections to the accessory olfactory bulb (AOB), I have analyzed the mouse V2R repertoire and identified 4 receptor sub-families. Receptors belonging to three of the sub-families are expressed by a random subset of VNO neurons, while receptors from one of the sub-families are expressed primarily by neurons located in the most basal portion of the neuroepithelium. Eighty percent of the newly identified V2Rs appear to encode non-functional proteins. In order to determine if the zones of V2R expression have a functional significance in the process of pheromone coding, the projection patterns of neurons expressing two specific V2Rs were analyzed in transgenic mouse lines generated with modified BACs. Two distinct patterns appear: neurons expressing a receptor with a basal expression pattern project to only one or a few glomeruli in a central portion of the posterior AOB, while neurons expressing a randomly distributed V2R project to multiple glomeruli within two large domains of stereotyped position in the posterior AOB. The organization of projection patterns does not appear to change during the course of development and is similar in both sexes. Finally, a rat V2R that displays a sexually dimorphic expression pattern was mis-expressed in transgenic mice constructed from a modified rat BAC. In these mice, neurons expressing the transgene do not display a sexually dimorphic expression pattern in the neuroepithelium, and their axons fail to project to defined glomeruli.
590 $a School code: 0084.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Neuroscience. $3 1017680
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710 2 0 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 63-04B.
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791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3051123