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Comparison of murine B7-1 and B7-2 i...

Beckerleg, Anne Marie Sabrina.

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Comparison of murine B7-1 and B7-2 in generating an anti-tumor immune response when delivered by recombinant vaccinia virus vaccination.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Comparison of murine B7-1 and B7-2 in generating an anti-tumor immune response when delivered by recombinant vaccinia virus vaccination./
作者:	Beckerleg, Anne Marie Sabrina.
面頁冊數:	140 p.
附註:	Adviser: Drew M. Pardoll.
Contained By:	Dissertation Abstracts International63-03B.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3046417
ISBN:	0493605541

Comparison of murine B7-1 and B7-2 in generating an anti-tumor immune response when delivered by recombinant vaccinia virus vaccination.
Beckerleg, Anne Marie Sabrina.

Comparison of murine B7-1 and B7-2 in generating an anti-tumor immune response when delivered by recombinant vaccinia virus vaccination. - 140 p.

Adviser: Drew M. Pardoll.

Thesis (Ph.D.)--The Johns Hopkins University, 2002.

Two of the most important costimulatory molecules for T cell activation are provided by the B7 family members B7-1(CD80) and B7-2(CD86). Both molecules bind to CD28 and CTLA-4, providing positive and negative signals respectively. In order to define biologic differences intrinsic to the B7-1 and B7-2 molecules themselves, double recombinant Vaccinia virus vectors were constructed which express antigens targeted to three distinct cellular compartments together with B7-1 and B7-2. Analysis of antigen-specific responses after immunization of mice with these vectors indicated that B7-2 selectively promotes cytotoxic T lymphocyte (CTL) generation for antigens expressed in all three compartments. Conversely, B7-1 selectively promotes humoral immunity. These results reveal distinct immunologic functions intrinsic to B7-1 and B7-2.

ISBN: 0493605541Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Comparison of murine B7-1 and B7-2 in generating an anti-tumor immune response when delivered by recombinant vaccinia virus vaccination.
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520 $a Two of the most important costimulatory molecules for T cell activation are provided by the B7 family members B7-1(CD80) and B7-2(CD86). Both molecules bind to CD28 and CTLA-4, providing positive and negative signals respectively. In order to define biologic differences intrinsic to the B7-1 and B7-2 molecules themselves, double recombinant Vaccinia virus vectors were constructed which express antigens targeted to three distinct cellular compartments together with B7-1 and B7-2. Analysis of antigen-specific responses after immunization of mice with these vectors indicated that B7-2 selectively promotes cytotoxic T lymphocyte (CTL) generation for antigens expressed in all three compartments. Conversely, B7-1 selectively promotes humoral immunity. These results reveal distinct immunologic functions intrinsic to B7-1 and B7-2.
520 $a However, despite the potent abilities of B7-1 and B7-2 to affect antigen-specific immune responses, attempts to augment tumor specific immune responses capable of protecting against tumor growth in vivo by vaccinating naïve mice with these vectors failed to result in increased tumor protection. In these experiments, improved CTL activity did not correspond with improved protection from tumor challenge which suggests that protective immunity may be mediated by more non-traditional effector mechanisms such as NK cell lysis, eosinophil activity, and macrophage secreted i-NOS toxicity.
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