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Hemodynamic and ventilatory response...

Garofano, Robert Phillip.

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Hemodynamic and ventilatory responses to steady state and progressive exercise in pediatric heart transplant recipients.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Hemodynamic and ventilatory responses to steady state and progressive exercise in pediatric heart transplant recipients./
Author:	Garofano, Robert Phillip.
Description:	110 p.
Notes:	Source: Dissertation Abstracts International, Volume: 58-03, Section: B, page: 1202.
Contained By:	Dissertation Abstracts International58-03B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9724830
ISBN:	0591336995

Hemodynamic and ventilatory responses to steady state and progressive exercise in pediatric heart transplant recipients.
Garofano, Robert Phillip.

Hemodynamic and ventilatory responses to steady state and progressive exercise in pediatric heart transplant recipients. - 110 p.

Source: Dissertation Abstracts International, Volume: 58-03, Section: B, page: 1202.

Thesis (Ed.D.)--Columbia University Teachers College, 1997.

Some of the differences may be attributed to pharmacological therapies used to support a failing cardiovascular system before transplantation and to prevent graft rejection after transplantation.

ISBN: 0591336995Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Hemodynamic and ventilatory responses to steady state and progressive exercise in pediatric heart transplant recipients.
LDR:03481nam 2200361 a 45 001 927582
005 20110425
008 110425s1997 eng d
020 $a 0591336995
035 $a (UnM)AAI9724830
035 $a AAI9724830
040 $a UnM $c UnM
100 1 $a Garofano, Robert Phillip. $3 1251143
245 1 0 $a Hemodynamic and ventilatory responses to steady state and progressive exercise in pediatric heart transplant recipients.
300 $a 110 p.
500 $a Source: Dissertation Abstracts International, Volume: 58-03, Section: B, page: 1202.
500 $a Sponsor: Ronald E. De Meersman.
502 $a Thesis (Ed.D.)--Columbia University Teachers College, 1997.
520 $a Some of the differences may be attributed to pharmacological therapies used to support a failing cardiovascular system before transplantation and to prevent graft rejection after transplantation.
520 $a Transplanting the human heart has become a successful therapy for end stage heart disease. This study investigated the cardiopulmonary responses to submaximal and progressive exercise in children who have undergone orthotopic heart transplantation, and a group of control children.
520 $a Seventeen healthy volunteers and 22 pediatric orthotopic heart transplantation recipients (OHT) participated in this study. Healthy volunteers were age and gender matched to the OHT recipient. Metabolic gas exchange measurements were made at rest and during all levels of steady state submaximal and progressive exercise to near maximal levels. Cardiac output was measured during the last 30 seconds of a 4 minute steady state period of rest and exercise at unloaded cycling, 25% of peak OHT workload, and 50% of peak OHT workload. Oxygen uptake kinetics were measured breath by breath during the transition from rest to unloaded cycling exercise.
520 $a Cardiac output, stroke volume, and end tidal CO$\sb2$ (PETCO$\sb2$) were significantly lower (p $<$.05) during all levels of submaximal exercise. Oxygen consumption (VO$\sb2$) was significantly lower at all submaximal workloads. VO$\sb2$ at rest and after 2 minutes of unloaded steady state exercise was significantly lower for the OHT group when compared to controls.
520 $a There were significant differences (p $<$.05) between groups for progressive exercise. The OHT group had significantly lower, watts, VO$\sb2$, VCO$\sb2$, V$\sb{\rm E}$, O$\sb2$ pulse for all levels of progressive exercise. Heart rate increases were significantly higher for the OHT group at 20% of peak VO$\sb2$, and not different at 40% of peak workload. The heart rate response of the OHT group was significantly lower for 60%, 80%, and 100% of peak VO$\sb2$.
520 $a These results suggest that OHT recipients are limited by their inability to increase heart rate to achieve higher cardiac outputs during progressive exercise and possible limitations in stroke volume during submaximal exercise. Equally important are peripheral factors, i.e. changes in the enzyme composition and the structure of skeletal muscle after long periods of heart failure and deconditioning, that limit the utilization of oxygen during exercise.
590 $a School code: 0055.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
650 4 $a Health Sciences, Recreation. $3 1018003
650 4 $a Health Sciences, Rehabilitation and Therapy. $3 1017926
690 $a 0382
690 $a 0433
690 $a 0564
690 $a 0575
710 2 0 $a Columbia University Teachers College. $3 1250841
773 0 $t Dissertation Abstracts International $g 58-03B.
790 $a 0055
790 1 0 $a Meersman, Ronald E. De, $e advisor
791 $a Ed.D.
792 $a 1997
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9724830