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Polymorphism in manganese superoxide...

Genkinger, Jeanine Marie.

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Polymorphism in manganese superoxide dismutase, antioxidant intake and all-cause, cancer and cardiovascular disease mortality.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Polymorphism in manganese superoxide dismutase, antioxidant intake and all-cause, cancer and cardiovascular disease mortality./
Author:	Genkinger, Jeanine Marie.
Description:	268 p.
Notes:	Adviser: Elizabeth A. Platz.
Contained By:	Dissertation Abstracts International64-02B.
Subject:	Health Sciences, Oncology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3080663

Polymorphism in manganese superoxide dismutase, antioxidant intake and all-cause, cancer and cardiovascular disease mortality.
Genkinger, Jeanine Marie.

Polymorphism in manganese superoxide dismutase, antioxidant intake and all-cause, cancer and cardiovascular disease mortality. - 268 p.

Adviser: Elizabeth A. Platz.

Thesis (Ph.D.)--The Johns Hopkins University, 2003.

<italic>Conclusions</italic>. These findings support the general health recommendations to consume several fruits and vegetable servings daily.Subjects--Topical Terms:

1018566
Health Sciences, Oncology.

Polymorphism in manganese superoxide dismutase, antioxidant intake and all-cause, cancer and cardiovascular disease mortality.
LDR:03091nam 2200313 a 45 001 927564
005 20110425
008 110425s2003 eng d
035 $a (UnM)AAI3080663
035 $a AAI3080663
040 $a UnM $c UnM
100 1 $a Genkinger, Jeanine Marie. $3 1251125
245 1 0 $a Polymorphism in manganese superoxide dismutase, antioxidant intake and all-cause, cancer and cardiovascular disease mortality.
300 $a 268 p.
500 $a Adviser: Elizabeth A. Platz.
500 $a Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0662.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2003.
520 $a <italic>Conclusions</italic>. These findings support the general health recommendations to consume several fruits and vegetable servings daily.
520 $a <italic>Background</italic>. Exogenous oxidants and bodily processes produce endogenous oxidants, or free radicals, that can damage DNA, membranes and other body constituents, and may ultimately lead to cancer, cardiovascular disease, aging and premature death. Exogenous and endogenous antioxidants can react with free radicals to convert these oxidants to less harmful substances and thus, may protect against certain diseases. To understand the independent and joint relations of exogenous (C47T polymorphism in manganese superoxide dismutase) and endogenous antioxidants (dietary intake of fruits and vegetables, vitamin C, vitamin E and beta-carotene) with all-cause, cancer and cardiovascular disease mortality, a prospective cohort study was conducted among participants of the Washington County, MD CLUE I and II studies.
520 $a <italic>Methods</italic>. Included were men and women participants of the CLUE studies who donated a blood sample in both 1974 and 1989 and completed the modified Block food frequency questionnaire in 1989 (N = 6,151). The FFQ estimated nutrients and food intake over the past year. The C47T genotypes (CC, CT, TT) were determined by the Taqman<super>®</super> fluorogenic method for nucleic acid analysis (PE Corporation, Foster City, CA). Individuals were followed from 1989 to time of death or January 2002.
520 $a <italic>Results</italic>. Overall, higher intake of fruits and vegetables was associated with a lower risk of all-cause, cancer and cardiovascular mortality. No consistent associations were observed with antioxidant nutrients (Vitamin C, E, and beta-carotene) and all-cause, cancer and cardiovascular disease mortality. The C47T MnSOD polymorphism was not associated with all-cause, cancer and cardiovascular mortality. The relation between C47T MnSOD polymorphism and all-cause, cancer and cardiovascular disease mortality was not modified by exposure to oxidants (smoking) or antioxidants (fruit and vegetable intake).
590 $a School code: 0098.
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Health Sciences, Pathology. $3 1017854
650 4 $a Health Sciences, Public Health. $3 1017659
690 $a 0571
690 $a 0573
690 $a 0992
710 2 0 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 64-02B.
790 $a 0098
790 1 0 $a Platz, Elizabeth A., $e advisor
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3080663