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Proteomics and morphology demonstrat...

Shen, Xia.

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Proteomics and morphology demonstrate mitochondrial changes in diabetic cardiomyopathy.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Proteomics and morphology demonstrate mitochondrial changes in diabetic cardiomyopathy./
Author:	Shen, Xia.
Description:	31 p.
Notes:	Adviser: Paul N. Epstein.
Contained By:	Masters Abstracts International41-02.
Subject:	Health Sciences, Pathology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1410585
ISBN:	0493820116

Proteomics and morphology demonstrate mitochondrial changes in diabetic cardiomyopathy.
Shen, Xia.

Proteomics and morphology demonstrate mitochondrial changes in diabetic cardiomyopathy. - 31 p.

Adviser: Paul N. Epstein.

Thesis (M.S.)--University of Louisville, 2002.

Our proteomic and morphologic analyses indicate that mitochondria are an important target of diabetic cardiomyopathy. Protection by overexpression of mitochondrial MnSOD indicates that ROS are involved in this damage.

ISBN: 0493820116Subjects--Topical Terms:

1017854
Health Sciences, Pathology.

Proteomics and morphology demonstrate mitochondrial changes in diabetic cardiomyopathy.
LDR:02782nam 2200301 a 45 001 927542
005 20110425
008 110425s2002 eng d
020 $a 0493820116
035 $a (UnM)AAI1410585
035 $a AAI1410585
040 $a UnM $c UnM
100 1 $a Shen, Xia. $3 1251102
245 1 0 $a Proteomics and morphology demonstrate mitochondrial changes in diabetic cardiomyopathy.
300 $a 31 p.
500 $a Adviser: Paul N. Epstein.
500 $a Source: Masters Abstracts International, Volume: 41-02, page: 0532.
502 $a Thesis (M.S.)--University of Louisville, 2002.
520 $a Our proteomic and morphologic analyses indicate that mitochondria are an important target of diabetic cardiomyopathy. Protection by overexpression of mitochondrial MnSOD indicates that ROS are involved in this damage.
520 $a Diabetic cardiomyopathy (DCM) is a common complication leading to accelerated cardiovascular failure in diabetic patients. Even though the exact mechanism(s) behind this disease still remain unclear, research from several laboratories including our own suggests that reactive oxygen species (ROS) play a very important role in the development of DCM.
520 $a In our lab, we have developed and characterized a diabetic transgenic mice line, designated OVE26, which clearly develops diabetic cardiomyopathy. Comparison of protein expression patterns in the hearts of 120-day-old control and diabetic mice reveals 22 proteins that are differentially expressed in OVE26 mice hearts, most of which are involved in energy metabolism. Surprisingly, 10 of 20 proteins that are identified by mass spectrometry are located in mitochondria, suggesting mitochondria as a critical target for ROS damage. The finding of the up-regulation of all 10 proteins also corresponds well with the concept that moderate oxidative stress can stimulate mitochondrial biosynthesis to compensate for the impaired cell functions. Study on mitochondrial morphology also shows abnormal cardiac structure and damage, further pointing to mitochondria as one of the major sites of ROS attack in diabetic cardiomyopathy.
520 $a In an effort to prevent the mitochondrial damage we saw in diabetic hearts, we have developed transgenic lines that overexpress the main mitochondrial antioxidant protein, MnSOD specifically in cardiomyocytes. Preliminary data from the transgenic mice that overexpress MnSOD in diabetic heart showed that this antioxidant enzyme was effective in protecting the morphology of the diabetic heart.
590 $a School code: 0110.
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0571
710 2 0 $a University of Louisville. $3 1017614
773 0 $t Masters Abstracts International $g 41-02.
790 $a 0110
790 1 0 $a Epstein, Paul N., $e advisor
791 $a M.S.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1410585