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Cell death pathways in irradiated pr...

Bromfield, Gillian Patricia.

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Cell death pathways in irradiated prostate cells.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Cell death pathways in irradiated prostate cells./
Author:	Bromfield, Gillian Patricia.
Description:	89 p.
Notes:	Adviser: Robert G. Bristow.
Contained By:	Masters Abstracts International41-03.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ74050
ISBN:	0612740501

Cell death pathways in irradiated prostate cells.
Bromfield, Gillian Patricia.

Cell death pathways in irradiated prostate cells. - 89 p.

Adviser: Robert G. Bristow.

Thesis (M.Sc.)--University of Toronto (Canada), 2002.

In this thesis, the molecular and cellular responses following ionizing radiation of two normal and three malignant prostate cell lines were determined to further understand the clinical response of prostate cancer to radiotherapy. Relative levels of apoptosis, clonogenic survival and permanent-cell cycle arrest were determined amongst the cultures, as well as molecular data pertaining to cell-cycle checkpoints and apoptosis. Radiation-induced apoptosis was minimal in all cell lines and did not correlate with results from clonogenic survival, suggesting that apoptosis is not the dominant mode of radiation-induced cell killing in prostate tissues <italic>in vitro</italic>. Expression data confirmed a p53-dependent induction of p21<super>WAF1</super>, but the levels of bax or bcl-2 observed did not correlate with apoptosis or long-term survival data. Furthermore, these results suggest that proliferative arrest is a critical endpoint for these experiments. Future strategies for predicting the response of prostate cancer to radiotherapy should focus on factors that determine permanent cell cycle arrest following irradiation.

ISBN: 0612740501Subjects--Topical Terms:

1017686
Biology, Cell.

Cell death pathways in irradiated prostate cells.
LDR:02018nam 2200301 a 45 001 927535
005 20110425
008 110425s2002 eng d
020 $a 0612740501
035 $a (UnM)AAIMQ74050
035 $a AAIMQ74050
040 $a UnM $c UnM
100 1 $a Bromfield, Gillian Patricia. $3 1251094
245 1 0 $a Cell death pathways in irradiated prostate cells.
300 $a 89 p.
500 $a Adviser: Robert G. Bristow.
500 $a Source: Masters Abstracts International, Volume: 41-03, page: 0724.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2002.
520 $a In this thesis, the molecular and cellular responses following ionizing radiation of two normal and three malignant prostate cell lines were determined to further understand the clinical response of prostate cancer to radiotherapy. Relative levels of apoptosis, clonogenic survival and permanent-cell cycle arrest were determined amongst the cultures, as well as molecular data pertaining to cell-cycle checkpoints and apoptosis. Radiation-induced apoptosis was minimal in all cell lines and did not correlate with results from clonogenic survival, suggesting that apoptosis is not the dominant mode of radiation-induced cell killing in prostate tissues <italic>in vitro</italic>. Expression data confirmed a p53-dependent induction of p21<super>WAF1</super>, but the levels of bax or bcl-2 observed did not correlate with apoptosis or long-term survival data. Furthermore, these results suggest that proliferative arrest is a critical endpoint for these experiments. Future strategies for predicting the response of prostate cancer to radiotherapy should focus on factors that determine permanent cell cycle arrest following irradiation.
590 $a School code: 0779.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Health Sciences, Radiology. $3 1019076
690 $a 0379
690 $a 0574
690 $a 0760
690 $a 0992
710 2 0 $a University of Toronto (Canada). $3 1017674
773 0 $t Masters Abstracts International $g 41-03.
790 $a 0779
790 1 0 $a Bristow, Robert G., $e advisor
791 $a M.Sc.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ74050